Thermodynamic rules for the design of high affinity HIV-1 protease inhibitors with adaptability to mutations and high selectivity towards unwanted targets

Medicine & Life Sciences

• Human immunodeficiency virus 1 p16 protease 100%
• HIV Protease Inhibitors 97%
• Thermodynamics 81%
• Drug Resistance 61%
• Protease Inhibitors 46%
• Mutation 37%
• Patient Compliance 21%
• HIV Infections 19%
• HIV-1 19%
• Guidelines 14%
• Databases 13%
• Drug Therapy 13%
• Therapeutics 3%

Chemical Compounds

• Protease Inhibitor 78%
• Mutation 56%
• Thermodynamics 41%
• Kd 33%
• Antiretroviral 31%
• Compliance 26%