Thermodynamic and kinetic studies of a stoichiometric model of energetic metabolism under starvation conditions

Sonia Cortassa, Miguel A. Aon, Daniel Thomas

Research output: Contribution to journalArticlepeer-review

Abstract

A stoichiometric model of anaerobic glycolysis is presented and the influence on its dynamics by the ATP-consuming membrane transport processes and substrate input rate are studied. The model is represented by a system of four ODE (ordinary differential equations), mass conservation equations and functions of state variables, such as thermodynamic efficiency. A low substrate input rate provokes damped oscillations while a high enrgy load determines sustained oscillations in all the metabolites and in thermodynamic efficiency. Due to the lack of linearity between fluxes and forces in the oscillatory region it may be stated that oscillations appear when the system is kinetically controlled.

Original languageEnglish (US)
Pages (from-to)249-255
Number of pages7
JournalFEMS microbiology letters
Volume66
Issue number1-3
DOIs
StatePublished - Jan 1 1990

Keywords

  • Anaerobic glycolysis
  • Kinetic/thermodynamic control
  • Oscillations
  • Starvation

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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