Thermoacoustic wave generation and propagation in the cornea - The potential for damage

Alvin K. Benson, C. Brent Bargeron, Samuel L. Brady, Adam W. Denning, Leland M. Page, Russell L. McCally

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Carbon dioxide lasers are used in numerous applications that involve human exposure to the radiation that can produce ocular injury. The objective of this study is to show that the thermal gradient produced in the eye by the radiation from an 80 ns CO2 laser pulse can generate a thermoacoustical tensile pressure wave with large enough magnitude to rupture the epithelial layer of the cornea. A Gaussian-shaped temperature distribution will be employed. It is assumed that the corneal tissue is inhomogeneous, with the density and wave velocity varying slowly in space. Under these conditions, the acoustical wave equation is decoupled into two first-order partial differential equations, one that propagates energy into the eye from the point of thermoacoustical wave generation, and the other toward the front of the eye. These equations are solved numerically using the Lax-Wendroff numerical method. A compressional wave generated in the epithelial tissue of the cornea due to the thermal gradient of the laser arrives at the air-tear layer interface with a pressure amplitude of-6600 Pa. When this wave is reflected back into the eye, the resulting tensile pressure wave has a tensile strength of approximately 4.6 × 10 8 Pa/m just inside of the epithelial layer of the cornea. This is an order of magnitude larger than what is necessary to produce cellular damage to the cornea.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6426
DOIs
StatePublished - 2007
EventOphthalmic Technologies XVII - San Jose, CA, United States
Duration: Jan 20 2007Jan 23 2007

Other

OtherOphthalmic Technologies XVII
CountryUnited States
CitySan Jose, CA
Period1/20/071/23/07

Fingerprint

Thermoacoustics
Thermal gradients
Tissue
Carbon dioxide lasers
Radiation
Wave equations
Partial differential equations
Laser pulses
Numerical methods
Temperature distribution
Tensile strength
Lasers
Air

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Benson, A. K., Brent Bargeron, C., Brady, S. L., Denning, A. W., Page, L. M., & McCally, R. L. (2007). Thermoacoustic wave generation and propagation in the cornea - The potential for damage. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6426). [642628] https://doi.org/10.1117/12.712253

Thermoacoustic wave generation and propagation in the cornea - The potential for damage. / Benson, Alvin K.; Brent Bargeron, C.; Brady, Samuel L.; Denning, Adam W.; Page, Leland M.; McCally, Russell L.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6426 2007. 642628.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Benson, AK, Brent Bargeron, C, Brady, SL, Denning, AW, Page, LM & McCally, RL 2007, Thermoacoustic wave generation and propagation in the cornea - The potential for damage. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6426, 642628, Ophthalmic Technologies XVII, San Jose, CA, United States, 1/20/07. https://doi.org/10.1117/12.712253
Benson AK, Brent Bargeron C, Brady SL, Denning AW, Page LM, McCally RL. Thermoacoustic wave generation and propagation in the cornea - The potential for damage. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6426. 2007. 642628 https://doi.org/10.1117/12.712253
Benson, Alvin K. ; Brent Bargeron, C. ; Brady, Samuel L. ; Denning, Adam W. ; Page, Leland M. ; McCally, Russell L. / Thermoacoustic wave generation and propagation in the cornea - The potential for damage. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6426 2007.
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