Thermal effect of intravascular MR imaging using an MR imaging-guidewire: An in vivo laboratory and histopathological evaluation

Xiaoming Yang, Christopher J. Yeung, Hongxiu Ji, Jean Michel Serfaty, Ergin Atalar

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Intravascular magnetic resonance (MR) imaging to guide interventional procedures is a rapidly growing field. A primary concern with these new techniques is their thermal safety. The purpose of this study was to evaluate, in vivo, the thermal effect of an MR imaging-guidewire (MRIG) for intravascular MR imaging (IVMRI). Material/Methods: Two indications of potentially adverse local heating were investigated: blood coagulation disorders and pathologic changes in target vessels. Experiments were performed on ten rabbits with a 1.5 T MR scanner. Using a 0.64-mm MRIG as the RF receiver, we imaged the target aorta using a fast spin-echo pulse sequence with an average specific absorption rate (SAR) of 0.6 W/kg. The total MR imaging time was approximately 70 minutes. Results: There were no abnormal value changes of the coagulation factors between pre- and post-IVMRI, no clinical manifestations of blood coagulation disorders, and, histopathologically, no thermal damage in target vessels. Conclusions: This study demonstrates, from a pathophysiological point of view, the potential safe use of the MR imaging-guidewire for intravascular MR imaging. Further study is required to precisely define the boundaries of these safe operating parameters.

Original languageEnglish (US)
JournalMedical Science Monitor
Volume8
Issue number7
StatePublished - 2002

Keywords

  • Interventional MR
  • Intravascular MR imaging
  • MR safety

ASJC Scopus subject areas

  • Medicine(all)

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