There is no overkill in biochemistry: Har Gobind Khorana, a pioneer in membrane biology

Sadashiva Karnik, Sriram Subramaniam

Research output: Contribution to journalArticlepeer-review

Abstract

Har Gobind Khorana pioneered study of transmembrane proteins at highest resolution possible through the application of biochemical techniques. His research on bacteriorhodopsin, a retinal based light driven proton pump from Halobacterium halobium spanned a range of ground breaking studies from membrane reconstitution, complete denaturation and refolding of a polytopic membrane protein, gene synthesis combined with genetically-directed protein modification and protein dynamic/kinetic analysis. His courage for tackling tough biochemical problems through enormous enthusiasm, building of a multi disciplinary team and maintain focus is a lesson for generations to come.

Original languageEnglish (US)
Pages (from-to)1157-1164
Number of pages8
JournalResonance
Volume17
Issue number12
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • bacteriorhodopsin
  • Gobind Khorana
  • light-induced signaling
  • transmembrane proteins

ASJC Scopus subject areas

  • General
  • Education

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