Therapy with granulocyte colony-stimulating factor in systemic lupus erythematosus may be associated with severe flares

Irene M. Vasiliu, Michelle A. Petri, Alan N. Baer

Research output: Contribution to journalArticlepeer-review

Abstract

Recombinant human granulocyte colony-stimulating factor (G-CSF) has been used for treatment of febrile neutropenia in systemic lupus erythematosus (SLE) and other systemic rheumatic diseases. We describe 2 patients with SLE with disease flares with irreversible loss of renal function in association with G-CSF therapy. Eighteen patients with SLE treated with G-CSF for neutropenia have been reported, of whom 4 developed mild disease flares or cutaneous vasculitis. Our experience suggests that G-CSF therapy should be used with considerable caution in patients with SLE.

Original languageEnglish (US)
Pages (from-to)1878-1880
Number of pages3
JournalJournal of Rheumatology
Volume33
Issue number9
StatePublished - Sep 2006

Keywords

  • Colony-stimulating factors
  • Infection
  • Neutropenia
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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