Abstract
Recombinant human granulocyte colony-stimulating factor (G-CSF) has been used for treatment of febrile neutropenia in systemic lupus erythematosus (SLE) and other systemic rheumatic diseases. We describe 2 patients with SLE with disease flares with irreversible loss of renal function in association with G-CSF therapy. Eighteen patients with SLE treated with G-CSF for neutropenia have been reported, of whom 4 developed mild disease flares or cutaneous vasculitis. Our experience suggests that G-CSF therapy should be used with considerable caution in patients with SLE.
Original language | English (US) |
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Pages (from-to) | 1878-1880 |
Number of pages | 3 |
Journal | Journal of Rheumatology |
Volume | 33 |
Issue number | 9 |
State | Published - Sep 2006 |
Keywords
- Colony-stimulating factors
- Infection
- Neutropenia
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology