Therapy-related acute leukemia

J. E. Karp, C. B. Sarkodee-Adoo

Research output: Contribution to journalReview articlepeer-review

Abstract

Acute leukemias that arise as a result of treatment with DNA-damaging agents exhibit distinctive molecular, genetic, and clinico-pathologic features. In this timely article, the authors dissect the pathogenetic basis of therapy-related leukemias, elucidating important molecular mechanisms through which DNA damage causes these disorders. The authors also discuss how these molecular aberrations translate into specific clinical syndromes, and in addition, point out potential molecular targets for the development of innovative treatment approaches.

Original languageEnglish (US)
Pages (from-to)71-81
Number of pages11
JournalClinics in laboratory medicine
Volume20
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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