@article{648112b460a14df6a1ab3d91e6d7ccf4,
title = "Therapy of scleritis with cytotoxic agents",
abstract = "Four patients with severe anterior scleritis that had not responded to conventional therapy were treated with cytotoxic immunosuppressive alkylating agents alone (one case) or in combination with prednisone (three cases). Two of the patients had Wegener's granulomatosis, one pyoderma gangrenosum, and one rheumatoid vasculitis. All patients responded well to this therapy with a decrease in inflammation and a healing of the sclera. Other systemic manifestations of the underlying diseases often responded well also.",
author = "Jampol, {Lee M.} and Carole West and Goldberg, {Morton F.}",
note = "Funding Information: Case 1—A 36-year-old black man was healthy until 1970, when he noted the onset of a papulono-dular skin rash, skin ulcerations, and arthralgias of the knees. A clinical diagnosis of pyoderma gangre-nosum was made. Two subsequent skin biopsies confirmed the diagnosis. The patient was treated with systemic prednisone and dapsone. On Oct. 20, 1973, he had a red, painful left eye with a tender preauricular node. The patient had discontinued systemic medications on his own several months previously. Systemic and topical antibiotics did not improve the condition. Examination one week later revealed necrotizing sclerokeratitis in the left eye with a corneal ring ulcer nasally, most marked from the 6 o'clock to the 11 o'clock meridian (Fig. 1), and 4+ flare and cells in the anterior chamber. Visual acuity was R.E.: 6/9 (20/30); L.E.: 6/120 (20/400). Three millimeters of left proptosis was present. Intraocular pressure and fundus examination were normal. Bacterial and fungal cultures of the cornea were negative. The patient was admitted to the hospital where examination for collagen vascular diseases yielded a negative lupus erythematosus From the University of Illinois Eye and Ear Infirmary, Chicago, Illinois. This study was supported in part by an unrestricted grant from Research to Prevent Blindness, Inc., New York City, and by a research grant from the Illinois Society for the Prevention of Blindness, Chicago (Dr. Goldberg).",
year = "1978",
month = aug,
language = "English (US)",
volume = "86",
pages = "266--271",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "2",
}