Therapy for experimental intraabdominal sepsis: Comparison of four cephalosporins with clindamycin plus gentamicin

T. J. Louie, A. B. Onderdonk, S. L. Gorbach, J. G. Bartlett

Research output: Contribution to journalArticlepeer-review

Abstract

An experimental model of intraabdominal sepsis in rats was used for evaluation of treatment with four cephalosporins: cephalothin, cefazolin, cefoxitin, and cefamandole. Doses were 115 mg of each of the cephalosporins/kg and, in additional experiments, 350 mg of cephalothin or cefazolin/kg. Response to treatment was evaluated by mortality rate and the incidence of intrabdominal abscess. All four cephalosporins and gentamicin produced a similar reduction in mortality rates. There was a marked variation in incidence of abscess dependent upon the cephalosporin selected and the dosage tested. Regimens most effective in reducing abscesses were clindamycin, low-dose cefoxitin, or high-dose cephalothin.

Original languageEnglish (US)
Pages (from-to)18-24
Number of pages7
JournalJournal of Infectious Diseases
Volume135
Issue numbersup.march
DOIs
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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