TY - JOUR
T1 - Therapy for experimental intraabdominal sepsis
T2 - Comparison of four cephalosporins with clindamycin plus gentamicin
AU - Louie, T. J.
AU - Onderdonk, A. B.
AU - Gorbach, S. L.
AU - Bartlett, J. G.
PY - 1977
Y1 - 1977
N2 - An experimental model of intraabdominal sepsis in rats was used for evaluation of treatment with four cephalosporins: cephalothin, cefazolin, cefoxitin, and cefamandole. Doses were 115 mg of each of the cephalosporins/kg and, in additional experiments, 350 mg of cephalothin or cefazolin/kg. Response to treatment was evaluated by mortality rate and the incidence of intrabdominal abscess. All four cephalosporins and gentamicin produced a similar reduction in mortality rates. There was a marked variation in incidence of abscess dependent upon the cephalosporin selected and the dosage tested. Regimens most effective in reducing abscesses were clindamycin, low-dose cefoxitin, or high-dose cephalothin.
AB - An experimental model of intraabdominal sepsis in rats was used for evaluation of treatment with four cephalosporins: cephalothin, cefazolin, cefoxitin, and cefamandole. Doses were 115 mg of each of the cephalosporins/kg and, in additional experiments, 350 mg of cephalothin or cefazolin/kg. Response to treatment was evaluated by mortality rate and the incidence of intrabdominal abscess. All four cephalosporins and gentamicin produced a similar reduction in mortality rates. There was a marked variation in incidence of abscess dependent upon the cephalosporin selected and the dosage tested. Regimens most effective in reducing abscesses were clindamycin, low-dose cefoxitin, or high-dose cephalothin.
UR - http://www.scopus.com/inward/record.url?scp=0017595117&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017595117&partnerID=8YFLogxK
U2 - 10.1093/infdis/135.supplement.s18
DO - 10.1093/infdis/135.supplement.s18
M3 - Article
C2 - 321707
AN - SCOPUS:0017595117
SN - 0022-1899
VL - 135
SP - 18
EP - 24
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - sup.march
ER -