Therapies for tuberculosis and AIDS: Myeloid-derived suppressor cells in focus

Anca Dorhoi, Leigh A. Kotzé, Jay A. Berzofsky, Yongjun Sui, Dmitry I. Gabrilovich, Ankita Garg, Richard Hafner, Shabaana A. Khader, Ulrich E. Schaible, Stefan H.E. Kaufmann, Gerhard Walzl, Manfred B. Lutz, Robert N. Mahon, Suzanne Ostrand-Rosenberg, William Bishai, Nelita Du Plessis

Research output: Contribution to journalReview article

Abstract

The critical role of suppressive myeloid cells in immune regulation has come to the forefront in cancer research, with myeloidderived suppressor cells (MDSCs) as a main oncology immunotherapeutic target. Recent improvement and standardization of criteria classifying tumor-induced MDSCs have led to unified descriptions and also promoted MDSC research in tuberculosis (TB) and AIDS. Despite convincing evidence on the induction of MDSCs by pathogen-derived molecules and inflammatory mediators in TB and AIDS, very little attention has been given to their therapeutic modulation or roles in vaccination in these diseases. Clinical manifestations in TB are consequences of complex host-pathogen interactions and are substantially affected by HIV infection. Here we summarize the current understanding and knowledge gaps regarding the role of MDSCs in HIV and Mycobacterium tuberculosis (co)infections. We discuss key scientific priorities to enable application of this knowledge to the development of novel strategies to improve vaccine efficacy and/or implementation of enhanced treatment approaches. Building on recent findings and potential for cross-fertilization between oncology and infection biology, we highlight current challenges and untapped opportunities for translating new advances in MDSC research into clinical applications for TB and AIDS.

Original languageEnglish (US)
Pages (from-to)2789-2799
Number of pages11
JournalJournal of Clinical Investigation
Volume130
Issue number6
DOIs
StatePublished - Jun 1 2020

ASJC Scopus subject areas

  • Medicine(all)

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    Dorhoi, A., Kotzé, L. A., Berzofsky, J. A., Sui, Y., Gabrilovich, D. I., Garg, A., Hafner, R., Khader, S. A., Schaible, U. E., Kaufmann, S. H. E., Walzl, G., Lutz, M. B., Mahon, R. N., Ostrand-Rosenberg, S., Bishai, W., & Du Plessis, N. (2020). Therapies for tuberculosis and AIDS: Myeloid-derived suppressor cells in focus. Journal of Clinical Investigation, 130(6), 2789-2799. https://doi.org/10.1172/JCI136288