Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease

An L. Moens, David A Kass

Research output: Contribution to journalArticle

Abstract

Tetrahydrobiopterin is the reduced unconjugated pterin that serves as an essential cofactor for the normal enzymatic function of the aromatic amino acid hydroxylases and for the nitric oxide synthases (NOS). Its role in the latter biochemistry is being increasing appreciated, as depletion or oxidation of BH4 results in a condition of NOS uncoupling, resulting in a nitroso-oxidative imbalance. Recent experimental studies support an important pathophysiologic role of BH4 deficiency as well as the therapeutic potential of BH4 repletion for hypertension, endothelial dysfunction, atherosclerosis, diabetes, cardiac hypertrophic remodeling, and heart failure. In addition to BH4, studies are also examining the potential role of folic acid therapy, because folic acid can enhance BH4 levels and the NOS coupling state. This review summarizes these recent studies focusing on the biochemistry and pharmacology of BH4 and its potential role for treating cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)238-246
Number of pages9
JournalJournal of Cardiovascular Pharmacology
Volume50
Issue number3
DOIs
StatePublished - Sep 2007

Fingerprint

Vascular Diseases
Nitric Oxide Synthase
Heart Diseases
Folic Acid
Biochemistry
Pterins
Aromatic Amino Acids
Phenylketonurias
Mixed Function Oxygenases
Atherosclerosis
Cardiovascular Diseases
Therapeutics
Heart Failure
Pharmacology
Hypertension
sapropterin

Keywords

  • eNOS uncoupling
  • Superoxide
  • Tetrahydrobiopterin

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease. / Moens, An L.; Kass, David A.

In: Journal of Cardiovascular Pharmacology, Vol. 50, No. 3, 09.2007, p. 238-246.

Research output: Contribution to journalArticle

@article{989dcd6a939349b28e8d2ed1d547513b,
title = "Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease",
abstract = "Tetrahydrobiopterin is the reduced unconjugated pterin that serves as an essential cofactor for the normal enzymatic function of the aromatic amino acid hydroxylases and for the nitric oxide synthases (NOS). Its role in the latter biochemistry is being increasing appreciated, as depletion or oxidation of BH4 results in a condition of NOS uncoupling, resulting in a nitroso-oxidative imbalance. Recent experimental studies support an important pathophysiologic role of BH4 deficiency as well as the therapeutic potential of BH4 repletion for hypertension, endothelial dysfunction, atherosclerosis, diabetes, cardiac hypertrophic remodeling, and heart failure. In addition to BH4, studies are also examining the potential role of folic acid therapy, because folic acid can enhance BH4 levels and the NOS coupling state. This review summarizes these recent studies focusing on the biochemistry and pharmacology of BH4 and its potential role for treating cardiovascular disease.",
keywords = "eNOS uncoupling, Superoxide, Tetrahydrobiopterin",
author = "Moens, {An L.} and Kass, {David A}",
year = "2007",
month = "9",
doi = "10.1097/FJC.0b013e318123f854",
language = "English (US)",
volume = "50",
pages = "238--246",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease

AU - Moens, An L.

AU - Kass, David A

PY - 2007/9

Y1 - 2007/9

N2 - Tetrahydrobiopterin is the reduced unconjugated pterin that serves as an essential cofactor for the normal enzymatic function of the aromatic amino acid hydroxylases and for the nitric oxide synthases (NOS). Its role in the latter biochemistry is being increasing appreciated, as depletion or oxidation of BH4 results in a condition of NOS uncoupling, resulting in a nitroso-oxidative imbalance. Recent experimental studies support an important pathophysiologic role of BH4 deficiency as well as the therapeutic potential of BH4 repletion for hypertension, endothelial dysfunction, atherosclerosis, diabetes, cardiac hypertrophic remodeling, and heart failure. In addition to BH4, studies are also examining the potential role of folic acid therapy, because folic acid can enhance BH4 levels and the NOS coupling state. This review summarizes these recent studies focusing on the biochemistry and pharmacology of BH4 and its potential role for treating cardiovascular disease.

AB - Tetrahydrobiopterin is the reduced unconjugated pterin that serves as an essential cofactor for the normal enzymatic function of the aromatic amino acid hydroxylases and for the nitric oxide synthases (NOS). Its role in the latter biochemistry is being increasing appreciated, as depletion or oxidation of BH4 results in a condition of NOS uncoupling, resulting in a nitroso-oxidative imbalance. Recent experimental studies support an important pathophysiologic role of BH4 deficiency as well as the therapeutic potential of BH4 repletion for hypertension, endothelial dysfunction, atherosclerosis, diabetes, cardiac hypertrophic remodeling, and heart failure. In addition to BH4, studies are also examining the potential role of folic acid therapy, because folic acid can enhance BH4 levels and the NOS coupling state. This review summarizes these recent studies focusing on the biochemistry and pharmacology of BH4 and its potential role for treating cardiovascular disease.

KW - eNOS uncoupling

KW - Superoxide

KW - Tetrahydrobiopterin

UR - http://www.scopus.com/inward/record.url?scp=34548748213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548748213&partnerID=8YFLogxK

U2 - 10.1097/FJC.0b013e318123f854

DO - 10.1097/FJC.0b013e318123f854

M3 - Article

C2 - 17878750

AN - SCOPUS:34548748213

VL - 50

SP - 238

EP - 246

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - 3

ER -