Therapeutic Potential of Neurotrophic Factors

Stephen McMahon, Beth Murinson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The term "neurotrophic factor" refers to the ability of a factor to nourish or support the growth of neurons and promote survival and growth of discrete subpopulations of neurons. Neurotrophic factors may protect neurons against cytotoxic insults, and, moreover, neurotrophic factors may offer important therapeutic opportunities that go beyond promoting survival. This chapter also illustrates some of the neurobiological roles of neurotrophic factors in mature animals and discuss how, in some contexts a dysregulation of neurotrophic factor expression may be an important contributor to the pathophysiological state. In these circumstances, a therapeutic potential exists for blocking particular neurotrophic effects. There are a number of families of neurotrophic factors, but two in particular have been studied for their neuroprotective effects. These are neurotrophins and the glial cell line-derived neurotrophic factor (GDNF) family. This chapter further reviews potential use of these neurotrophic factors in neurodegenerative disease.

Original languageEnglish (US)
Title of host publicationFrom NEUROSCIENCE To NEUROLOGY
PublisherElsevier Inc.
Pages419-431
Number of pages13
ISBN (Print)9780127389035
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

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