Therapeutic potential of nanoceria in regenerative medicine

Soumen Das, Srinivasulu Chigurupati, Janet Dowding, Prabhakaran Munusamy, Donald R. Baer, James F. McGinnis, Mark P. Mattson, William Self, Sudipta Seal

Research output: Contribution to journalArticle

Abstract

Tissue engineering and regenerative medicine aim to achieve functional restoration of tissue or cells damaged through disease, aging, or trauma. Advancement of tissue engineering requires innovation in the field of three-dimensional scaffolding and functionalization with bioactive molecules. Nanotechnology offers advanced materials with patterned nano-morphologies for cell growth and different molecular substrates that can support cell survival and functions. Cerium oxide nanoparticles (nanoceria) can control intracellular as well as extracellular reactive oxygen and nitrogen species. Recent findings suggest that nanoceria can enhance long-term cell survival, enable cell migration and proliferation, and promote stem cell differentiation. Moreover, the self-regenerative property of nanoceria permits a small dose to remain catalytically active for an extended time. This review summarizes the possibilities and applications of nanoceria in the field of tissue engineering and regenerative medicine.

Original languageEnglish (US)
Pages (from-to)976-983
Number of pages8
JournalMRS Bulletin
Volume39
Issue number11
DOIs
StatePublished - Nov 13 2014
Externally publishedYes

Keywords

  • biomedical
  • Ce
  • nanostructure
  • rare-earths
  • surface chemistry

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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  • Cite this

    Das, S., Chigurupati, S., Dowding, J., Munusamy, P., Baer, D. R., McGinnis, J. F., Mattson, M. P., Self, W., & Seal, S. (2014). Therapeutic potential of nanoceria in regenerative medicine. MRS Bulletin, 39(11), 976-983. https://doi.org/10.1557/mrs.2014.221