TY - JOUR
T1 - Therapeutic potential of gastric electrical stimulation for obesity and its possible mechanisms
T2 - A preliminary canine study
AU - Ouyang, Hui
AU - Yin, Jieyun
AU - Chen, Jiande D.Z.
N1 - Funding Information:
Manuscript received March 11, 2002; accepted August 26, 2002. From the Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, USA. Support was provided by: a research grant from the Brown Foundation. Address for reprint requests: Jiande Chen, University of Texas Medical Branch 301 University Boulevard 1108 Strand, Room 221 Galveston, Texas 77555-0632, USA.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Our aim was to investigate the effects of gastric electrical stimulation on food intake, weight, gastric myoelectrical, and parasympathetic activity. Dogs were implanted with serosal electrodes and a subcutaneous stimulator. The stimulator was turned on and off alternately every month for 4 months. Food intake, weight, gastric myoelectrical activity, and electrocardiograms were recorded. Daily food intake and weight were significantly decreased during the months with stimulation. Stimulation did not show any acute effect on gastric myoelectrical activity; however, it chronically and significantly impaired gastric myoelectrical activity in the fed state, but not in the fasting state. The parasympathetic activity in the fasting state assessed from the spectral analysis of heart rate variability was markedly decreased with stimulation both acutely and chronically. In conclusion, chronic gastric electrical stimulation results in a reduction in food intake, weight loss, a reduction in parasympathetic activity, and chronic inhibition of gastric myoelectrical activity. These data suggest that gastric electrical stimulation is a potential therapy for the treatment of obesity and its inhibitory effect on food intake and weight may involve both muscles and the vagal afferent pathway.
AB - Our aim was to investigate the effects of gastric electrical stimulation on food intake, weight, gastric myoelectrical, and parasympathetic activity. Dogs were implanted with serosal electrodes and a subcutaneous stimulator. The stimulator was turned on and off alternately every month for 4 months. Food intake, weight, gastric myoelectrical activity, and electrocardiograms were recorded. Daily food intake and weight were significantly decreased during the months with stimulation. Stimulation did not show any acute effect on gastric myoelectrical activity; however, it chronically and significantly impaired gastric myoelectrical activity in the fed state, but not in the fasting state. The parasympathetic activity in the fasting state assessed from the spectral analysis of heart rate variability was markedly decreased with stimulation both acutely and chronically. In conclusion, chronic gastric electrical stimulation results in a reduction in food intake, weight loss, a reduction in parasympathetic activity, and chronic inhibition of gastric myoelectrical activity. These data suggest that gastric electrical stimulation is a potential therapy for the treatment of obesity and its inhibitory effect on food intake and weight may involve both muscles and the vagal afferent pathway.
KW - Gastric electrical stimulation
KW - Gastric myoelectrical activity
KW - Heart rate variability
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=0037382636&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037382636&partnerID=8YFLogxK
U2 - 10.1023/A:1022824406648
DO - 10.1023/A:1022824406648
M3 - Article
C2 - 12741458
AN - SCOPUS:0037382636
SN - 0163-2116
VL - 48
SP - 698
EP - 705
JO - Digestive diseases and sciences
JF - Digestive diseases and sciences
IS - 4
ER -