Therapeutic potential of extracellular vesicle-associated long noncoding RNA

Louis J. Born; John W. Harmon; Steven M. Jay

doi:10.1002/btm2.10172

Therapeutic potential of extracellular vesicle-associated long noncoding RNA

Louis J. Born, John W. Harmon, Steven M. Jay

School of Medicine

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Both extracellular vesicles (EVs) and long noncoding RNAs (lncRNAs) have been increasingly investigated as biomarkers, pathophysiological mediators, and potential therapeutics. While these two entities have often been studied separately, there are increasing reports of EV-associated lncRNA activity in processes such as oncogenesis as well as tissue repair and regeneration. Given the powerful nature and emerging translational impact of other noncoding RNAs such as microRNA (miRNA) and small interfering RNA, lncRNA therapeutics may represent a new frontier. While EVs are natural vehicles that transport and protect lncRNAs physiologically, they can also be engineered for enhanced cargo loading and therapeutic properties. In this review, we will summarize the activity of lncRNAs relevant to both tissue repair and cancer treatment and discuss the role of EVs in enabling the potential of lncRNA therapeutics.

Original language	English (US)
Article number	e10172
Journal	Bioengineering and Translational Medicine
Volume	5
Issue number	3
DOIs	https://doi.org/10.1002/btm2.10172
State	Published - Sep 1 2020

Keywords

exosomes
extracellular vesicles
lncRNA
microparticles
microvesicles

ASJC Scopus subject areas

Biotechnology
Biomedical Engineering
Pharmaceutical Science

Access to Document

10.1002/btm2.10172

Cite this

@article{4f532625638c488dbf402a2ccded99dd,

title = "Therapeutic potential of extracellular vesicle-associated long noncoding RNA",

abstract = "Both extracellular vesicles (EVs) and long noncoding RNAs (lncRNAs) have been increasingly investigated as biomarkers, pathophysiological mediators, and potential therapeutics. While these two entities have often been studied separately, there are increasing reports of EV-associated lncRNA activity in processes such as oncogenesis as well as tissue repair and regeneration. Given the powerful nature and emerging translational impact of other noncoding RNAs such as microRNA (miRNA) and small interfering RNA, lncRNA therapeutics may represent a new frontier. While EVs are natural vehicles that transport and protect lncRNAs physiologically, they can also be engineered for enhanced cargo loading and therapeutic properties. In this review, we will summarize the activity of lncRNAs relevant to both tissue repair and cancer treatment and discuss the role of EVs in enabling the potential of lncRNA therapeutics.",

keywords = "exosomes, extracellular vesicles, lncRNA, microparticles, microvesicles",

author = "Born, {Louis J.} and Harmon, {John W.} and Jay, {Steven M.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.",

year = "2020",

month = sep,

day = "1",

doi = "10.1002/btm2.10172",

language = "English (US)",

volume = "5",

journal = "Bioengineering and Translational Medicine",

issn = "2380-6761",

publisher = "John Wiley & Sons Inc.",

number = "3",

}

TY - JOUR

T1 - Therapeutic potential of extracellular vesicle-associated long noncoding RNA

AU - Born, Louis J.

AU - Harmon, John W.

AU - Jay, Steven M.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Both extracellular vesicles (EVs) and long noncoding RNAs (lncRNAs) have been increasingly investigated as biomarkers, pathophysiological mediators, and potential therapeutics. While these two entities have often been studied separately, there are increasing reports of EV-associated lncRNA activity in processes such as oncogenesis as well as tissue repair and regeneration. Given the powerful nature and emerging translational impact of other noncoding RNAs such as microRNA (miRNA) and small interfering RNA, lncRNA therapeutics may represent a new frontier. While EVs are natural vehicles that transport and protect lncRNAs physiologically, they can also be engineered for enhanced cargo loading and therapeutic properties. In this review, we will summarize the activity of lncRNAs relevant to both tissue repair and cancer treatment and discuss the role of EVs in enabling the potential of lncRNA therapeutics.

AB - Both extracellular vesicles (EVs) and long noncoding RNAs (lncRNAs) have been increasingly investigated as biomarkers, pathophysiological mediators, and potential therapeutics. While these two entities have often been studied separately, there are increasing reports of EV-associated lncRNA activity in processes such as oncogenesis as well as tissue repair and regeneration. Given the powerful nature and emerging translational impact of other noncoding RNAs such as microRNA (miRNA) and small interfering RNA, lncRNA therapeutics may represent a new frontier. While EVs are natural vehicles that transport and protect lncRNAs physiologically, they can also be engineered for enhanced cargo loading and therapeutic properties. In this review, we will summarize the activity of lncRNAs relevant to both tissue repair and cancer treatment and discuss the role of EVs in enabling the potential of lncRNA therapeutics.

KW - exosomes

KW - extracellular vesicles

KW - lncRNA

KW - microparticles

KW - microvesicles

UR - http://www.scopus.com/inward/record.url?scp=85088141385&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85088141385&partnerID=8YFLogxK

U2 - 10.1002/btm2.10172

DO - 10.1002/btm2.10172

M3 - Review article

C2 - 33005738

AN - SCOPUS:85088141385

SN - 2380-6761

VL - 5

JO - Bioengineering and Translational Medicine

JF - Bioengineering and Translational Medicine

IS - 3

M1 - e10172

ER -

Therapeutic potential of extracellular vesicle-associated long noncoding RNA

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this