Therapeutic perspectives for the treatment of Huntington's disease: Treating the whole body

Bronwen Martin, Erin Golden, Alex Keselman, Matthew Stone, Mark P. Mattson, Josephine M. Egan, Stuart Maudsley

Research output: Contribution to journalArticle

Abstract

Summary Huntington's disease (HD) is a tremendously debilitating disorder that strikes relatively young individuals and progresses rapidly over the next ten to fifteen years inducing a loss of cognitive and motor skills and eventually death occurs. The primary locus of the disorder is a polyglutamine expansion of the protein product of the huntingtin (htt) gene. The htt protein appears to be a scaffolding protein that orchestrates the complex assembly of multiple intracellular proteins involved in multiple processes, including vesicular movement and cell metabolism. The htt protein is ubiquitously expressed in human tissues but the predominance of the interest in the pathology lies in its effects on the central nervous system (CNS). Most of the current therapeutics for HD thus have been targeted at preventing neuronal damage in the CNS, however, a considerable body of evidence has been accumulating to suggest that the maintenance of a healthy nervous system is tightly linked with peripheral physiological health. Therefore treatment of both the peripheral and central pathophysiologies of HD could form the basis of a more effective HD therapeutic strategy.

Original languageEnglish (US)
Pages (from-to)237-250
Number of pages14
JournalHistology and Histopathology
Volume23
Issue number2
StatePublished - Feb 2008
Externally publishedYes

Keywords

  • Aggregation
  • Expansion
  • Huntingtin
  • Polyglutamine
  • Therapeutic

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine
  • Anatomy
  • Cell Biology

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    Martin, B., Golden, E., Keselman, A., Stone, M., Mattson, M. P., Egan, J. M., & Maudsley, S. (2008). Therapeutic perspectives for the treatment of Huntington's disease: Treating the whole body. Histology and Histopathology, 23(2), 237-250.