Abstract
The pharmacokinetics of doxycycline and cephalothin in genital tissues and serum were evaluated in 38 patients undergoing hysterectomy. Antibiotic concentrations in the ovary, fallopian tube, myometrium, cervix, and endometrium were measured at varying intervals after antibiotic administration. Cephalothin concentrations in tissues were critically dependent on the time interval between preoperative antibiotic administration and removal of the genital tract tissues, whereas doxycycline concentrations in tissues were consistently reproducible in the time frame evaluated (½ to 4½ hours after drug administration). Doxycycline endometrial concentrations were consistently higher than those measured elsewhere in the genital tract (P&0.05). These results are of importance in a reassessment of traditional approaches to antibiotic use in gynecologic surgery and in the management of pelvic inflammatory disease (PID).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 28-32 |
| Number of pages | 5 |
| Journal | Obstetrics and Gynecology |
| Volume | 55 |
| Issue number | 1 |
| State | Published - 1980 |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract. / Whelton, Andrew; Blanco, Lucas J.; Carter, Gordon G.; Craig, Timothy J.; Bryant, Henry H.; Herbst, Doris V.; King, Theodore M.
In: Obstetrics and Gynecology, Vol. 55, No. 1, 1980, p. 28-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract
AU - Whelton, Andrew
AU - Blanco, Lucas J.
AU - Carter, Gordon G.
AU - Craig, Timothy J.
AU - Bryant, Henry H.
AU - Herbst, Doris V.
AU - King, Theodore M.
PY - 1980
Y1 - 1980
N2 - The pharmacokinetics of doxycycline and cephalothin in genital tissues and serum were evaluated in 38 patients undergoing hysterectomy. Antibiotic concentrations in the ovary, fallopian tube, myometrium, cervix, and endometrium were measured at varying intervals after antibiotic administration. Cephalothin concentrations in tissues were critically dependent on the time interval between preoperative antibiotic administration and removal of the genital tract tissues, whereas doxycycline concentrations in tissues were consistently reproducible in the time frame evaluated (½ to 4½ hours after drug administration). Doxycycline endometrial concentrations were consistently higher than those measured elsewhere in the genital tract (P&0.05). These results are of importance in a reassessment of traditional approaches to antibiotic use in gynecologic surgery and in the management of pelvic inflammatory disease (PID).
AB - The pharmacokinetics of doxycycline and cephalothin in genital tissues and serum were evaluated in 38 patients undergoing hysterectomy. Antibiotic concentrations in the ovary, fallopian tube, myometrium, cervix, and endometrium were measured at varying intervals after antibiotic administration. Cephalothin concentrations in tissues were critically dependent on the time interval between preoperative antibiotic administration and removal of the genital tract tissues, whereas doxycycline concentrations in tissues were consistently reproducible in the time frame evaluated (½ to 4½ hours after drug administration). Doxycycline endometrial concentrations were consistently higher than those measured elsewhere in the genital tract (P&0.05). These results are of importance in a reassessment of traditional approaches to antibiotic use in gynecologic surgery and in the management of pelvic inflammatory disease (PID).
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UR - http://www.scopus.com/inward/citedby.url?scp=0018844920&partnerID=8YFLogxK
M3 - Article
C2 - 7352059
AN - SCOPUS:0018844920
VL - 55
SP - 28
EP - 32
JO - Obstetrics and Gynecology
JF - Obstetrics and Gynecology
SN - 0029-7844
IS - 1
ER -