Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract

Andrew Whelton; Lucas J. Blanco; Gordon G. Carter; Timothy J. Craig; Henry H. Bryant; Doris V. Herbst; Theodore M. King

Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract

Andrew Whelton, Lucas J. Blanco, Gordon G. Carter, Timothy J. Craig, Henry H. Bryant, Doris V. Herbst, Theodore M. King

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The pharmacokinetics of doxycycline and cephalothin in genital tissues and serum were evaluated in 38 patients undergoing hysterectomy. Antibiotic concentrations in the ovary, fallopian tube, myometrium, cervix, and endometrium were measured at varying intervals after antibiotic administration. Cephalothin concentrations in tissues were critically dependent on the time interval between preoperative antibiotic administration and removal of the genital tract tissues, whereas doxycycline concentrations in tissues were consistently reproducible in the time frame evaluated (½ to 4½ hours after drug administration). Doxycycline endometrial concentrations were consistently higher than those measured elsewhere in the genital tract (P&0.05). These results are of importance in a reassessment of traditional approaches to antibiotic use in gynecologic surgery and in the management of pelvic inflammatory disease (PID).

Original language	English (US)
Pages (from-to)	28-32
Number of pages	5
Journal	Obstetrics and Gynecology
Volume	55
Issue number	1
State	Published - 1980

ASJC Scopus subject areas

Obstetrics and Gynecology

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title = "Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract",

abstract = "The pharmacokinetics of doxycycline and cephalothin in genital tissues and serum were evaluated in 38 patients undergoing hysterectomy. Antibiotic concentrations in the ovary, fallopian tube, myometrium, cervix, and endometrium were measured at varying intervals after antibiotic administration. Cephalothin concentrations in tissues were critically dependent on the time interval between preoperative antibiotic administration and removal of the genital tract tissues, whereas doxycycline concentrations in tissues were consistently reproducible in the time frame evaluated (½ to 4½ hours after drug administration). Doxycycline endometrial concentrations were consistently higher than those measured elsewhere in the genital tract (P&0.05). These results are of importance in a reassessment of traditional approaches to antibiotic use in gynecologic surgery and in the management of pelvic inflammatory disease (PID).",

author = "Andrew Whelton and Blanco, {Lucas J.} and Carter, {Gordon G.} and Craig, {Timothy J.} and Bryant, {Henry H.} and Herbst, {Doris V.} and King, {Theodore M.}",

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AU - Whelton, Andrew

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AU - Bryant, Henry H.

AU - Herbst, Doris V.

AU - King, Theodore M.

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AB - The pharmacokinetics of doxycycline and cephalothin in genital tissues and serum were evaluated in 38 patients undergoing hysterectomy. Antibiotic concentrations in the ovary, fallopian tube, myometrium, cervix, and endometrium were measured at varying intervals after antibiotic administration. Cephalothin concentrations in tissues were critically dependent on the time interval between preoperative antibiotic administration and removal of the genital tract tissues, whereas doxycycline concentrations in tissues were consistently reproducible in the time frame evaluated (½ to 4½ hours after drug administration). Doxycycline endometrial concentrations were consistently higher than those measured elsewhere in the genital tract (P&0.05). These results are of importance in a reassessment of traditional approaches to antibiotic use in gynecologic surgery and in the management of pelvic inflammatory disease (PID).

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Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract

Abstract

ASJC Scopus subject areas

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