Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract

Andrew Whelton, Lucas J. Blanco, Gordon G. Carter, Timothy J. Craig, Henry H. Bryant, Doris V. Herbst, Theodore M. King

Research output: Contribution to journalArticle

Abstract

The pharmacokinetics of doxycycline and cephalothin in genital tissues and serum were evaluated in 38 patients undergoing hysterectomy. Antibiotic concentrations in the ovary, fallopian tube, myometrium, cervix, and endometrium were measured at varying intervals after antibiotic administration. Cephalothin concentrations in tissues were critically dependent on the time interval between preoperative antibiotic administration and removal of the genital tract tissues, whereas doxycycline concentrations in tissues were consistently reproducible in the time frame evaluated (½ to 4½ hours after drug administration). Doxycycline endometrial concentrations were consistently higher than those measured elsewhere in the genital tract (P&0.05). These results are of importance in a reassessment of traditional approaches to antibiotic use in gynecologic surgery and in the management of pelvic inflammatory disease (PID).

Original languageEnglish (US)
Pages (from-to)28-32
Number of pages5
JournalObstetrics and Gynecology
Volume55
Issue number1
StatePublished - 1980

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Cephalothin
Doxycycline
Anti-Bacterial Agents
Pelvic Inflammatory Disease
Gynecologic Surgical Procedures
Fallopian Tubes
Myometrium
Therapeutics
Endometrium
Hysterectomy
Cervix Uteri
Ovary
Pharmacokinetics
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Whelton, A., Blanco, L. J., Carter, G. G., Craig, T. J., Bryant, H. H., Herbst, D. V., & King, T. M. (1980). Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract. Obstetrics and Gynecology, 55(1), 28-32.

Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract. / Whelton, Andrew; Blanco, Lucas J.; Carter, Gordon G.; Craig, Timothy J.; Bryant, Henry H.; Herbst, Doris V.; King, Theodore M.

In: Obstetrics and Gynecology, Vol. 55, No. 1, 1980, p. 28-32.

Research output: Contribution to journalArticle

Whelton, A, Blanco, LJ, Carter, GG, Craig, TJ, Bryant, HH, Herbst, DV & King, TM 1980, 'Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract', Obstetrics and Gynecology, vol. 55, no. 1, pp. 28-32.
Whelton A, Blanco LJ, Carter GG, Craig TJ, Bryant HH, Herbst DV et al. Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract. Obstetrics and Gynecology. 1980;55(1):28-32.
Whelton, Andrew ; Blanco, Lucas J. ; Carter, Gordon G. ; Craig, Timothy J. ; Bryant, Henry H. ; Herbst, Doris V. ; King, Theodore M. / Therapeutic implications of doxycycline and cephalothin concentrations in the female genital tract. In: Obstetrics and Gynecology. 1980 ; Vol. 55, No. 1. pp. 28-32.
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