Therapeutic Hypothermia in Neurocritical Care

Vishank Arun Shah, Romergryko G. Geocadin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The neuroprotective benefits of therapeutic hypothermia (TH) have been known for several decades but have become conventional in clinical practice only over the last decade, after large randomized clinical trials (RCT) affirmed the benefits of TH in preventing neurologic injury, predominantly in cardiac arrest survivors. In neurocritical care, the applications of TH have been extended to several critical neurologic illnesses including refractory elevation in intracranial pressure (ICP), status epilepticus, ischemic stroke, and traumatic brain injury among others. The appropriate clinical use of TH requires understanding the postulated pathophysiologic mechanisms behind TH-induced neuroprotection, associated wanted and unwanted physiologic effects of TH, methods of inducing TH, and clinical care of patients during TH. All of these aspects will be addressed in this chapter.

Original languageEnglish (US)
Title of host publicationCurrent Clinical Neurology
PublisherHumana Press Inc.
Pages57-72
Number of pages16
DOIs
StatePublished - 2020

Publication series

NameCurrent Clinical Neurology
ISSN (Print)1559-0585
ISSN (Electronic)2524-4043

Keywords

  • Brain injury
  • Cardiac arrest
  • Fever
  • Rewarming
  • Shivering
  • Therapeutic hypothermia

ASJC Scopus subject areas

  • Clinical Neurology

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