Therapeutic Hypothermia for Acute Neurological Injuries

Lucia Rivera Lara, Jiaying Zhang, Susanne Muehlschlegel

Research output: Contribution to journalReview article

Abstract

Therapeutic hypothermia (TH) is the intentional reduction of core body temperature to 32°C to 35°C, and is increasingly applied by intensivists for a variety of acute neurological injuries to achieve neuroprotection and reduction of elevated intracranial pressure. TH improves outcomes in comatose patients after a cardiac arrest with a shockable rhythm, but other off-label applications exist and are likely to increase in the future. This comprehensive review summarizes the physiology and cellular mechanism of action of TH, as well as different means of TH induction and maintenance with potential side effects. Indications of TH are critically reviewed by disease entity, as reported in the most recent literature, and evidence-based recommendations are provided.

Original languageEnglish (US)
Pages (from-to)73-86
Number of pages14
JournalNeurotherapeutics
Volume9
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Induced Hypothermia
Wounds and Injuries
Intracranial Hypertension
Coma
Heart Arrest
Body Temperature
Maintenance

Keywords

  • cardiac arrest
  • hypothermia
  • hypoxic-ischemic encephalopathy
  • intracranial hypertension
  • neurocritical care
  • neurological outcome
  • perinatal asphyxia

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Pharmacology

Cite this

Therapeutic Hypothermia for Acute Neurological Injuries. / Rivera Lara, Lucia; Zhang, Jiaying; Muehlschlegel, Susanne.

In: Neurotherapeutics, Vol. 9, No. 1, 01.2012, p. 73-86.

Research output: Contribution to journalReview article

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