Therapeutic human papillomavirus DNA vaccination strategies to control cervical cancer

Research output: Contribution to journalComment/debate

Abstract

A persistent human papillomavirus (HPV) infection is considered causal and necessary for the continued growth of cervical cancer. Thus, vaccination against HPV represents a plausible approach to prevent and treat cervical cancer. A report in the current issue of the European Journal of Immunology describes a therapeutic HPV DNA vaccination strategy using the HPV-16 E7 antigen fused to the invariant chain to enhance the E7-specific CD8+ and CD4+ T cell immune responses, resulting in a potent anti-tumor effect against E7-expressing tumors. Continued exploration of HPV therapeutic DNA vaccines may lead to eventual clinical application.

Original languageEnglish (US)
Pages (from-to)310-314
Number of pages5
JournalEuropean Journal of Immunology
Volume37
Issue number2
DOIs
StatePublished - Feb 2007

Keywords

  • Cancer
  • Human papillomavirus
  • Immunotherapy
  • Vaccination

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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