Therapeutic efficacy of 29 antimicrobial regimens in experimental intraabdominal sepsis.

John Bartlett, T. J. Louie, S. L. Gorbach, A. B. Onderdonk

Research output: Contribution to journalArticle

Abstract

An animal model of colonic perforation was used to examine the efficacy of 29 antimicrobial regimens in the treatment of intraabdominal sepsis. Efficacy was judged on mortality during the first 12 days after challenge and on the incidence of intraabdominal abscess noted at necropsy upon completion of the experiment. In general, antimicrobial agents that are active against coliform bacteria prevented early mortality, whereas drugs that are active against Bacteroides fragilis were most effective in reducing the incidence of late abscess formation. Exceptions were metronidazole, which produced a significant reduction in early mortality, and chloramphenicol, which caused only a modest reduction in the incidence of abscess. Optimal results were obtained with several regimens that showed good in vitro activity against both coliforms and B. fragilis.

Original languageEnglish (US)
Pages (from-to)535-542
Number of pages8
JournalReviews of Infectious Diseases
Volume3
Issue number3
StatePublished - May 1981
Externally publishedYes

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Abscess
Bacteroides fragilis
Sepsis
Mortality
Incidence
Metronidazole
Chloramphenicol
Anti-Infective Agents
Therapeutics
Animal Models
Bacteria
Pharmaceutical Preparations
In Vitro Techniques

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Therapeutic efficacy of 29 antimicrobial regimens in experimental intraabdominal sepsis. / Bartlett, John; Louie, T. J.; Gorbach, S. L.; Onderdonk, A. B.

In: Reviews of Infectious Diseases, Vol. 3, No. 3, 05.1981, p. 535-542.

Research output: Contribution to journalArticle

Bartlett, John ; Louie, T. J. ; Gorbach, S. L. ; Onderdonk, A. B. / Therapeutic efficacy of 29 antimicrobial regimens in experimental intraabdominal sepsis. In: Reviews of Infectious Diseases. 1981 ; Vol. 3, No. 3. pp. 535-542.
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