Therapeutic effects of topical dexamethasone on experimental brain tumors and peritumoral brain edema.

Shozo Nakazawa, Yukio Ireda, Benjamin Solomon, Carson, Donlin M. Long

Research output: Contribution to journalArticle

Abstract

The mechanisms of beneficial action of steroids on peritumoral brain edema (BE) remain controversial. Steroids, although effective in reducing peritumoral BE when administered systemically, are limited by many systemic complications. To deter mine if topical dexamethasone(Dx)by osmotic pump to brain tumor beds would not only control peritumoral BE, but also lead to suppression of tumor growth, we studied experimental brain tumors produced in 102 rabbits by implanted VX2 carcinoma cells, Animals were separated into three groups : (1) untreated group, (2) systemic Dx treat ed group, (3) topical Dx treated group. Systemic or topical Dx did not control tumor growth and peritumoral brain edema, however both groups resulted in a significant increase in survival relation to the untreated group.

Original languageEnglish (US)
Pages (from-to)143-145
Number of pages3
JournalDrug Delivery System
Volume7
Issue number2
DOIs
StatePublished - 1992

Keywords

  • brain edema
  • dexamethasone
  • osmotic pump

ASJC Scopus subject areas

  • Pharmaceutical Science

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