Therapeutic Drug Monitoring in Obese Patients

Ventzislava Hristova, William Clarke

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Health care is increasingly challenged by issues of clinically managing obese patients; this is of increased interest because the proportion of obese people in the general population is higher than ever and continues to increase. Obesity impacts the distribution of drugs and has been shown to impact metabolism and renal clearance as well. One clinical treatment of chronic obesity, bariatric surgery, results in rapid changes to drug absorption and distribution. For drugs with an already high interindividual pharmacokinetics (PK) variability, this can present significant challenges to drug management. This chapter discusses therapeutic drug monitoring as a tool for drug management in obese patients as well as bariatric surgery patients.

Original languageEnglish (US)
Title of host publicationClinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions, and Pharmacogenomics
PublisherElsevier Inc.
Pages231-243
Number of pages13
ISBN (Electronic)9780128020524
ISBN (Print)9780128020258
DOIs
StatePublished - May 17 2016

Keywords

  • Bariatric surgery
  • Dosage adjustment
  • Drug toxicity
  • Obesity

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Hristova, V., & Clarke, W. (2016). Therapeutic Drug Monitoring in Obese Patients. In Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions, and Pharmacogenomics (pp. 231-243). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802025-8.00010-6