Therapeutic and prognostic significance of PARP-1 in advanced mycosis fungoides and Sezary syndrome

David Lemchak, Swati Banerjee, Shaunak S. Digambar, Brian L. Hood, Thomas P. Conrads, Jaroslaw Jedrych, Larisa Geskin, Oleg E. Akilov

Research output: Contribution to journalArticle

Abstract

While mycosis fungoides (MF) is typically an indolent malignancy, it may infrequently undertake an aggressive course. We used proteomic analyses to identify a biomarker of the aggressive course of MF. Results of this investigation demonstrated that PARP-1, heat-shock protein family A (Hsp70) member 1 like (HSAP1L), Hsp70 member 1A (HSPA1A), ATP-depending RNA helicase (DDX17) and the α-isoform of lamina-associated polypeptide 2 (TMPO) had higher expression in aggressive disease versus non-aggressive. Moreover, PARP-1 was overexpressed in patients with early stage of MF who developed later an aggressive disease. PARP-1 was evaluated as a new target for therapy, demonstrating the selective dose-dependent cytotoxic effect of PARP inhibitors on Sézary cells in comparison with non-malignant lymphocytes. In conclusion, we believe that PARP-1 may serve not only as a biomarker at initial biopsies for a disease that may become aggressive but also as a new therapeutic target of advanced MF and Sézary syndrome.

Original languageEnglish (US)
Pages (from-to)188-190
Number of pages3
JournalExperimental Dermatology
Volume27
Issue number2
DOIs
StatePublished - Feb 1 2018
Externally publishedYes

Keywords

  • biomarkers
  • cutaneous lymphoma
  • mycosis fungoides
  • PARP-1
  • Sezary syndrome

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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  • Cite this

    Lemchak, D., Banerjee, S., Digambar, S. S., Hood, B. L., Conrads, T. P., Jedrych, J., Geskin, L., & Akilov, O. E. (2018). Therapeutic and prognostic significance of PARP-1 in advanced mycosis fungoides and Sezary syndrome. Experimental Dermatology, 27(2), 188-190. https://doi.org/10.1111/exd.13477