Theranostic biocomposite scaffold membrane

Emmanuel Roussakis, Roger V. Ortines, Bret L. Pinsker, Cavin T. Mooers, Conor L. Evans, Lloyd S. Miller, Xiomara Calderón-Colón

Research output: Contribution to journalArticlepeer-review

Abstract

Acute and chronic wounds affect millions and are associated with billions of dollars in healthcare costs. The use of healing markers, biochemical cues from biocompatible matrices and materials, and their correlation with wound healing has the potential to generate valuable diagnostic, prognostic, and therapeutic information. In this study, we developed a collagen-dextran oxygen-sensing biocomposite scaffold membrane in which a phosphorescent oxygen sensor was incorporated to monitor physiological oxygen using in vivo phosphorescence imaging in a preclinical mouse model of wound healing. The oxygen-sensing biocomposite scaffold membrane enabled the noninvasive and longitudinal monitoring of oxygenation changes in vivo in an approach compatible with commercially available preclinical in vivo imaging system instruments. This study provides a new and novel capability where a biocomposite material can serve as a biocompatible, biodegradable theranostic platform to promote and assess tissue oxygenation during wound healing.

Original languageEnglish (US)
Pages (from-to)17-27
Number of pages11
JournalBiomaterials
Volume212
DOIs
StatePublished - Aug 2019

Keywords

  • Biocompatible and biodegradable scaffold
  • Collagen
  • Dextran
  • Healing markers
  • In vivo physiological measurement of oxygenation
  • Tissue oxygenation

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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