Theory of oxygen transport to tissue

Research output: Contribution to journalArticle

Abstract

This review focuses on the theory of oxygen transport to tissue and presents the state of the art in mathematical modeling of transport phenomena. Results obtained with the classic Krogh tissue-cylinder model and recent advances in mathematical modeling of hemoglobin-oxygen kinetics, the role of hemoglobin and myoglobin in facilitating oxygen diffusion, and the role of morphologic and hemodynamic heterogeneities in oxygen transport in the microcirculation are critically discussed. Mathematical models simulate different parts of the pathway of oxygen molecules from the red blood cell, through the plasma, the endothelial cell, other elements of the vascular wall, and the extra- and intracellular space. Special attention in the review is devoted to intracapillary transport. Models of pre- and postcapillary oxygen transport are also discussed. Applications to specific organs and tissues are reviewed, including skeletal muscle, myocardium, brain, lungs, arterial wall, and skin. Unresolved problems are identified.

Original languageEnglish (US)
Pages (from-to)257-321
Number of pages65
JournalCritical Reviews in Biomedical Engineering
Volume17
Issue number3
StatePublished - 1989

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Tissue
Oxygen
Hemoglobin
Microcirculation
Endothelial cells
Hemodynamics
Muscle
Brain
Skin
Blood
Cells
Mathematical models
Plasmas
Molecules
Kinetics

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Theory of oxygen transport to tissue. / Popel, Aleksander S.

In: Critical Reviews in Biomedical Engineering, Vol. 17, No. 3, 1989, p. 257-321.

Research output: Contribution to journalArticle

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