Theory for spiralling ions for 2D FT-ICR and comparison with precessing magnetization vectors in 2D NMR

Akansha Ashvani Sehgal, Philippe Pelupessy, Christian Rolando, Geoffrey Bodenhausen

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Two-dimensional (2D) Fourier transform ion cyclotron resonance (FT-ICR) offers an approach to mass spectrometry (MS) that pursuits similar objectives as MS/MS experiments. While the latter must focus on one ion species at a time, 2D FT ICR can examine all possible correlations due to ion fragmentation in a single experiment: correlations between precursors, charged and neutral fragments. We revisited the original 2D FT-ICR experiment that has hitherto fallen short of stimulating significant analytical applications, probably because it is technically demanding. These shortcomings can now be overcome by improved FT-ICR instrumentation and computer hard- and software. We seek to achieve a better understanding of the intricacies of the behavior of ions during a basic two-dimensional ICR sequence comprising three simple monochromatic pulses. Through simulations based on Lorentzian equations, we have mapped the ion trajectories for different pulse durations and phases.

Original languageEnglish (US)
Pages (from-to)9167-9175
Number of pages9
JournalPhysical Chemistry Chemical Physics
Volume18
Issue number13
DOIs
StatePublished - Apr 7 2016
Externally publishedYes

ASJC Scopus subject areas

  • General Physics and Astronomy
  • Physical and Theoretical Chemistry

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