Theoretical investigation of Ca2+ dynamics in normal and hypertensive vascular walls

A. Bezerianos, A. Kapela, Nikolaos M. Tsoukias

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Using a theoretical model of smooth muscle cell from rat mesenteric arterioles, we investigated calcium dynamics in normal and hypertensive vascular wall. The model incorporated a detailed description of plasma membrane, cytosol and intracellular stores. Inhibition of Na+-K+ pump (NaK) simulated the effect of ouabain in salt sensitive hypertension. The inhibition caused intracellular sodium accumulation that compromised or reversed Na +-Ca2+ exchanger (NCX) and increased resting [Ca 2+]i and reactivity to norepinephrine (NE). NCX inhibition could compensate the effect of NaK block on the agonist-induced Ca2+ plateau, but it further increased resting Ca2+ and NE-induced Ca2+ transients. These undesirable effects could be avoided by selective inhibition of the reverse mode of NCX. In conclusion, NaK blockade elevated Ca+ levels, in agreement with experimental data, and this effect was reduced by inhibition of NCX reverse mode. The results provide evidence for the beneficial effects of a new class of antihypertensive pharmaceuticals.

Original languageEnglish (US)
Title of host publication2006 Computers in Cardiology, CIC
Number of pages4
StatePublished - Dec 1 2006
Event2006 Computers in Cardiology, CIC - Valencia, Spain
Duration: Sep 17 2006Sep 20 2006

Publication series

NameComputers in Cardiology
ISSN (Print)0276-6574


Other2006 Computers in Cardiology, CIC

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine


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