Theoretical and experimental study of intercellular junction-induced sawtooth effect in cardiac cell-pairs

Vinod Sharma, Leslie Tung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present an analytical expression for the sawtooth amplitude (STA) in an isolated cell-pair with junctional resistance (Rj). Experimentally, STA was estimated in isolated guinea pig cell-pairs by optically recording transmembrane potential responses (Vm) with subcellular spatial resolution. We estimated STA to be approximately 14 mV for a 10 V/cm field. From theoretical calculations, this corresponds to an Rj of approximately 22 MΩ.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
ISSN (Print)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Sharma, V., & Tung, L. (1999). Theoretical and experimental study of intercellular junction-induced sawtooth effect in cardiac cell-pairs. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 1). IEEE.