The Ying-Yang of the virus-host interaction: Control of the DNA damage response

Renfeng Li, S. Diane Hayward

Research output: Contribution to journalArticle

Abstract

Evaluation of: Nikitin PA, Yan CM, Forte E et al.: An ATM/Chk2-mediated DNA damage-responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells. Cell. Host Microbe 8(6), 510-522 (2010). Viruses have evolved elegant strategies to manipulate the host while the host counters with defense systems including the interferon response, apoptosis and the DNA damage response (DDR). Viruses have multiple strategies for manipulating the DDR and the same virus can even activate or inhibit the DDR at different stages of infection. Epstein-Barr virus (EBV) is implicated in several human cancers, including Burkitt's lymphoma, nasopharyngeal carcinoma, post-transplant lymphoproliferative disease and HIV-associated lymphomas. Although multiple viral proteins have been implicated in EBV-associated malignancies, the cellular pathways that control EBV-induced transformation and tumorigenesis remain incompletely understood. In this study, Nikitin et al. demonstrate that early EBV infection induces a cellular DDR that restricts virus-mediated transformation. The EBV-encoded EBNA3C protein subsequently attenuates this response to favor transformation and immortalization of host cells.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalFuture microbiology
Volume6
Issue number4
DOIs
StatePublished - Apr 2011

Keywords

  • ATM/CHK2
  • B-cell transformation
  • DNA damage response
  • Epstein-Barr virus
  • tumorigenesis

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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