The Yin and Yang of signaling in Tregs and TH17 cells

Fan Pan, Huimin Fan, Ling Lu, Zhongmin Liu, Shuiping Jiang

Research output: Contribution to journalArticlepeer-review

Abstract

Substantial advances in our understanding of the developmental and functional relationship between regulatory T cells (Tregs) and T helper 17 (TH17) cells and their potential clinical applications have been made. In response to these break-throughs, the second international conference entitled "China Tregs/Th17 2010 Shanghai Conference," held in Shanghai, China, was dedicated to this topic. Various types of T regs and TH17 cells, as well as their relevant cytokines, were discussed. Here, we summarize some of the findings shared at the conference, specifically focusing on the biology of TH17 cells, including interleukin-17 (IL-17)-producing innate cells, Tregs, and the factors that control the critical balance between Tregs and cells of the TH17 lineage.

Original languageEnglish (US)
Article numbermr4
JournalScience signaling
Volume4
Issue number165
DOIs
StatePublished - Mar 22 2011

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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