The World Health Organisation 2016 classification of penile carcinomas: A review and update from the International Society of Urological Pathology expert-driven recommendations

Antonio L. Cubilla, Elsa F. Velazquez, Mahul B. Amin, Jonathan Ira Epstein, Daniel M. Berney, Cathy M. Corbishley

Research output: Contribution to journalArticle

Abstract

The International Society of Urological Pathology (ISUP) held an expert-driven penile cancer conference in Boston in March 2015, which focused on the new World Health Organisation (WHO) classification of penile cancer: human papillomavirus (HPV)-related tumours and histological grading. The conference was preceded by an online survey of the ISUP members, and the results were used to initiate discussions. Because of the rarity of penile tumours, this was not a consensus but an expert-driven conference aimed at assisting pathologists who do not see these tumours on a regular basis. After a justification for the novel separation of penile squamous cell carcinomas into HPV-related and non-HPV-related-carcinomas, the histological classification of penile carcinoma was proposed; this system was also accepted subsequently by the WHO for subtyping of penile carcinomas (2016). A description of HPV-related neoplasms, which may be recognised by their histological features, was presented, and p16 was recommended as a surrogate indicator of HPV. A three-tier grading system was recommended for penile squamous carcinomas; this was also adopted by the WHO (2016). Many of the distinctive histological subtypes of squamous cell carcinoma of the penis are associated with distinct grades, based on the squamous cell carcinoma subtype histological features.

Original languageEnglish (US)
JournalHistopathology
DOIs
StateAccepted/In press - Jan 1 2018

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Squamous Cell Carcinoma
Penile Neoplasms
Pathology
Carcinoma
Neoplasms
Neoplasm Grading
Penis

Keywords

  • Carcinoma
  • Expert recommendations
  • ISUP
  • Penile cancer
  • WHO 2016 classification

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

The World Health Organisation 2016 classification of penile carcinomas : A review and update from the International Society of Urological Pathology expert-driven recommendations. / Cubilla, Antonio L.; Velazquez, Elsa F.; Amin, Mahul B.; Epstein, Jonathan Ira; Berney, Daniel M.; Corbishley, Cathy M.

In: Histopathology, 01.01.2018.

Research output: Contribution to journalArticle

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