The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders

Update 2010 on the treatment of acute bipolar depression

WFSBP Task Force On Treatment Guidelines For Bipolar Disorders

Research output: Contribution to journalReview article

Abstract

Objectives. These guidelines are based on a first edition that was published in 2002, and have been edited and updated with the available scientific evidence until September 2009. Their purpose is to supply a systematic overview of all scientific evidence pertaining to the treatment of acute bipolar depression in adults. Methods. The data used for these guidelines have been extracted from a MEDLINE and EMBASE search, from the clinical trial database clinicaltrials.gov, from recent proceedings of key conferences, and from various national and international treatment guidelines. Their scientific rigor was categorised into six levels of evidence (AF). As these guidelines are intended for clinical use, the scientific evidence was finally assigned different grades of recommendation to ensure practicability. Results. We identified 10 pharmacological monotherapies or combination treatments with at least limited positive evidence for efficacy in bipolar depression, several of them still experimental and backed up only by a single study. Only one medication was considered to be sufficiently studied to merit full positive evidence. Conclusions. Although major advances have been made since the first edition of this guideline in 2002, there are many areas which still need more intense research to optimize treatment. The majority of treatment recommendations is still based on limited data and leaves considerable areas of uncertainty.

Original languageEnglish (US)
Pages (from-to)81-109
Number of pages29
JournalWorld Journal of Biological Psychiatry
Volume11
Issue number2
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Biological Psychiatry
Bipolar Disorder
Guidelines
MEDLINE
Uncertainty
Clinical Trials
Databases
Pharmacology
Research

Keywords

  • Acute treatment
  • Antidepressants
  • Antipsychotics
  • Bipolar disorder
  • Depression
  • Electroconvulsive therapy
  • Evidence-based guidelines
  • Mood stabiliser
  • Pharmacotherapy
  • Psychotherapy

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders : Update 2010 on the treatment of acute bipolar depression. / WFSBP Task Force On Treatment Guidelines For Bipolar Disorders.

In: World Journal of Biological Psychiatry, Vol. 11, No. 2, 01.01.2010, p. 81-109.

Research output: Contribution to journalReview article

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title = "The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders: Update 2010 on the treatment of acute bipolar depression",
abstract = "Objectives. These guidelines are based on a first edition that was published in 2002, and have been edited and updated with the available scientific evidence until September 2009. Their purpose is to supply a systematic overview of all scientific evidence pertaining to the treatment of acute bipolar depression in adults. Methods. The data used for these guidelines have been extracted from a MEDLINE and EMBASE search, from the clinical trial database clinicaltrials.gov, from recent proceedings of key conferences, and from various national and international treatment guidelines. Their scientific rigor was categorised into six levels of evidence (AF). As these guidelines are intended for clinical use, the scientific evidence was finally assigned different grades of recommendation to ensure practicability. Results. We identified 10 pharmacological monotherapies or combination treatments with at least limited positive evidence for efficacy in bipolar depression, several of them still experimental and backed up only by a single study. Only one medication was considered to be sufficiently studied to merit full positive evidence. Conclusions. Although major advances have been made since the first edition of this guideline in 2002, there are many areas which still need more intense research to optimize treatment. The majority of treatment recommendations is still based on limited data and leaves considerable areas of uncertainty.",
keywords = "Acute treatment, Antidepressants, Antipsychotics, Bipolar disorder, Depression, Electroconvulsive therapy, Evidence-based guidelines, Mood stabiliser, Pharmacotherapy, Psychotherapy",
author = "{WFSBP Task Force On Treatment Guidelines For Bipolar Disorders} and Heinz Grunze and Eduard Vieta and Goodwin, {Guy M.} and Charles Bowden and Licht, {Rasmus W.} and Mller, {Hans Jrgen} and Siegfried Kasper and M{\"o}ller, {Hans J{\"u}rgen} and Hagop Akiskal and Ayuso-Gutierrez, {Jos{\'e} Luis} and Michael Bauer and Per Bech and Michael Berk and Istvan Bitter and Graham Burrows and Joseph Calabrese and Giovanni Cassano and Marcelo Cetkovich-Bakmas and Cookson, {John C.} and Ferrier, {I. Nicol} and Gattaz, {Wagner F.} and Goodwin, {Frederik K.} and Gerhard Heinze and Teruhiko Higuchi and Hirschfeld, {Robert M.} and Cyril Hoeschl and Edith Holsboer-Trachsler and Jamison, {Kay Redfield} and Kay Jamison and Martin Keller and E. Kostukova and Hever Kruger and Parmanand Kulhara and Yves Lecruibier and Veronica Larach and Odd Lingjaerde and Henrik Lublin and Mario Maj and Julien Mendlewicz and Camacho, {Roberto Miranda} and Philip Mitchell and S. Mosolov and Stuart Montgomery and Charles Nemeroff and Willem Nolen and Paykel, {Eugene S.} and Post, {Robert M.} and Stanislaw Puzynski and Zoltan Rihmer and Rybakowski, {Janusz K.}",
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T2 - Update 2010 on the treatment of acute bipolar depression

AU - WFSBP Task Force On Treatment Guidelines For Bipolar Disorders

AU - Grunze, Heinz

AU - Vieta, Eduard

AU - Goodwin, Guy M.

AU - Bowden, Charles

AU - Licht, Rasmus W.

AU - Mller, Hans Jrgen

AU - Kasper, Siegfried

AU - Möller, Hans Jürgen

AU - Akiskal, Hagop

AU - Ayuso-Gutierrez, José Luis

AU - Bauer, Michael

AU - Bech, Per

AU - Berk, Michael

AU - Bitter, Istvan

AU - Burrows, Graham

AU - Calabrese, Joseph

AU - Cassano, Giovanni

AU - Cetkovich-Bakmas, Marcelo

AU - Cookson, John C.

AU - Ferrier, I. Nicol

AU - Gattaz, Wagner F.

AU - Goodwin, Frederik K.

AU - Heinze, Gerhard

AU - Higuchi, Teruhiko

AU - Hirschfeld, Robert M.

AU - Hoeschl, Cyril

AU - Holsboer-Trachsler, Edith

AU - Jamison, Kay Redfield

AU - Jamison, Kay

AU - Keller, Martin

AU - Kostukova, E.

AU - Kruger, Hever

AU - Kulhara, Parmanand

AU - Lecruibier, Yves

AU - Larach, Veronica

AU - Lingjaerde, Odd

AU - Lublin, Henrik

AU - Maj, Mario

AU - Mendlewicz, Julien

AU - Camacho, Roberto Miranda

AU - Mitchell, Philip

AU - Mosolov, S.

AU - Montgomery, Stuart

AU - Nemeroff, Charles

AU - Nolen, Willem

AU - Paykel, Eugene S.

AU - Post, Robert M.

AU - Puzynski, Stanislaw

AU - Rihmer, Zoltan

AU - Rybakowski, Janusz K.

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KW - Antidepressants

KW - Antipsychotics

KW - Bipolar disorder

KW - Depression

KW - Electroconvulsive therapy

KW - Evidence-based guidelines

KW - Mood stabiliser

KW - Pharmacotherapy

KW - Psychotherapy

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