The widening sphere of influence of HOXB7 in solid tumors

Maria Cristina Errico, Kideok Jin, Saraswati Sukumar, Alessandra Caré

Research output: Contribution to journalReview article

Abstract

Strong lines of evidence have established a critical role for the homeodomain protein HOXB7 in cancer. Specifically, molecular and cellular studies have demonstrated that HOXB7 is a master regulatory gene, capable of orchestrating a variety of target molecules, resulting in the activation of several oncogenic pathways. HOXB7 overexpression correlates with clinical progression and poor outcome of cancer patients. Specific inhibition of HOXB7 is particularly relevant in cancers still lacking effective therapies, such as tamoxifen-resistant breast cancer and melanoma. Mechanistic studies are providing additional targets of therapy, and biomarker studies are further establishing its importance in early diagnosis and prognosis.

Original languageEnglish (US)
Pages (from-to)2857-2862
Number of pages6
JournalCancer Research
Volume76
Issue number10
DOIs
StatePublished - May 15 2016

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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