The WHO classification of tumors of the nervous system

Paul Kleihues, David N. Louis, Bernd W. Scheithauer, Lucy B. Rorke, Guido Reifenberger, Peter C. Burger, Webster K. Cavenee

Research output: Contribution to journalArticle

Abstract

The new World Health Organization (WHO) classification of nervous system tumors, published in 2000, emerged from a 1999 international consensus conference of neuropathologists. New entities include chordoid glioma of the third ventricle, cerebellar liponeurocytoma, atypical teratoid/rhabdoid tumor, and perineurioma. Several histological variants were added, including tanycytic ependymoma, large cell medulloblastoma, and rhabdoid meningioma. The WHO grading scheme was updated and, for meningiomas, extensively revised. In recognition of the emerging role of molecular diagnostic approaches to tumor classification, genetic profiles have been emphasized, as in the distinct subtypes of glioblastoma and the already clinically useful 1p and 19q markers for oligodendroglioma and 22q/INI1 for atypical teratoid/rhabdoid tumors. In accord with the new WHO Blue Book series, the actual classification is accompanied by extensive descriptions and illustrations of clinicopathological characteristics of each tumor type, including molecular genetic features, predictive factors, and separate chapters on inherited tumor syndromes. The 2000 WHO classification of nervous system tumors aims at being used and implemented by the neuro-oncology and biomedical research communities worldwide.

Original languageEnglish (US)
Pages (from-to)215-225
Number of pages11
JournalJournal of Neuropathology and Experimental Neurology
Volume61
Issue number3
StatePublished - 2002
Externally publishedYes

Fingerprint

Nervous System Neoplasms
Meningioma
Nerve Sheath Neoplasms
Notochord
Oligodendroglioma
Ependymoma
Neoplasms
Medulloblastoma
Third Ventricle
Molecular Pathology
Glioblastoma
Glioma
Biomedical Research
Molecular Biology
Typical Teratoid Rhabdoid Tumor
Atypical Teratoid Tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Kleihues, P., Louis, D. N., Scheithauer, B. W., Rorke, L. B., Reifenberger, G., Burger, P. C., & Cavenee, W. K. (2002). The WHO classification of tumors of the nervous system. Journal of Neuropathology and Experimental Neurology, 61(3), 215-225.

The WHO classification of tumors of the nervous system. / Kleihues, Paul; Louis, David N.; Scheithauer, Bernd W.; Rorke, Lucy B.; Reifenberger, Guido; Burger, Peter C.; Cavenee, Webster K.

In: Journal of Neuropathology and Experimental Neurology, Vol. 61, No. 3, 2002, p. 215-225.

Research output: Contribution to journalArticle

Kleihues, P, Louis, DN, Scheithauer, BW, Rorke, LB, Reifenberger, G, Burger, PC & Cavenee, WK 2002, 'The WHO classification of tumors of the nervous system', Journal of Neuropathology and Experimental Neurology, vol. 61, no. 3, pp. 215-225.
Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC et al. The WHO classification of tumors of the nervous system. Journal of Neuropathology and Experimental Neurology. 2002;61(3):215-225.
Kleihues, Paul ; Louis, David N. ; Scheithauer, Bernd W. ; Rorke, Lucy B. ; Reifenberger, Guido ; Burger, Peter C. ; Cavenee, Webster K. / The WHO classification of tumors of the nervous system. In: Journal of Neuropathology and Experimental Neurology. 2002 ; Vol. 61, No. 3. pp. 215-225.
@article{8a914193b74846f38bde6614c9df79a6,
title = "The WHO classification of tumors of the nervous system",
abstract = "The new World Health Organization (WHO) classification of nervous system tumors, published in 2000, emerged from a 1999 international consensus conference of neuropathologists. New entities include chordoid glioma of the third ventricle, cerebellar liponeurocytoma, atypical teratoid/rhabdoid tumor, and perineurioma. Several histological variants were added, including tanycytic ependymoma, large cell medulloblastoma, and rhabdoid meningioma. The WHO grading scheme was updated and, for meningiomas, extensively revised. In recognition of the emerging role of molecular diagnostic approaches to tumor classification, genetic profiles have been emphasized, as in the distinct subtypes of glioblastoma and the already clinically useful 1p and 19q markers for oligodendroglioma and 22q/INI1 for atypical teratoid/rhabdoid tumors. In accord with the new WHO Blue Book series, the actual classification is accompanied by extensive descriptions and illustrations of clinicopathological characteristics of each tumor type, including molecular genetic features, predictive factors, and separate chapters on inherited tumor syndromes. The 2000 WHO classification of nervous system tumors aims at being used and implemented by the neuro-oncology and biomedical research communities worldwide.",
author = "Paul Kleihues and Louis, {David N.} and Scheithauer, {Bernd W.} and Rorke, {Lucy B.} and Guido Reifenberger and Burger, {Peter C.} and Cavenee, {Webster K.}",
year = "2002",
language = "English (US)",
volume = "61",
pages = "215--225",
journal = "American Journal of Psychotherapy",
issn = "0002-9564",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - The WHO classification of tumors of the nervous system

AU - Kleihues, Paul

AU - Louis, David N.

AU - Scheithauer, Bernd W.

AU - Rorke, Lucy B.

AU - Reifenberger, Guido

AU - Burger, Peter C.

AU - Cavenee, Webster K.

PY - 2002

Y1 - 2002

N2 - The new World Health Organization (WHO) classification of nervous system tumors, published in 2000, emerged from a 1999 international consensus conference of neuropathologists. New entities include chordoid glioma of the third ventricle, cerebellar liponeurocytoma, atypical teratoid/rhabdoid tumor, and perineurioma. Several histological variants were added, including tanycytic ependymoma, large cell medulloblastoma, and rhabdoid meningioma. The WHO grading scheme was updated and, for meningiomas, extensively revised. In recognition of the emerging role of molecular diagnostic approaches to tumor classification, genetic profiles have been emphasized, as in the distinct subtypes of glioblastoma and the already clinically useful 1p and 19q markers for oligodendroglioma and 22q/INI1 for atypical teratoid/rhabdoid tumors. In accord with the new WHO Blue Book series, the actual classification is accompanied by extensive descriptions and illustrations of clinicopathological characteristics of each tumor type, including molecular genetic features, predictive factors, and separate chapters on inherited tumor syndromes. The 2000 WHO classification of nervous system tumors aims at being used and implemented by the neuro-oncology and biomedical research communities worldwide.

AB - The new World Health Organization (WHO) classification of nervous system tumors, published in 2000, emerged from a 1999 international consensus conference of neuropathologists. New entities include chordoid glioma of the third ventricle, cerebellar liponeurocytoma, atypical teratoid/rhabdoid tumor, and perineurioma. Several histological variants were added, including tanycytic ependymoma, large cell medulloblastoma, and rhabdoid meningioma. The WHO grading scheme was updated and, for meningiomas, extensively revised. In recognition of the emerging role of molecular diagnostic approaches to tumor classification, genetic profiles have been emphasized, as in the distinct subtypes of glioblastoma and the already clinically useful 1p and 19q markers for oligodendroglioma and 22q/INI1 for atypical teratoid/rhabdoid tumors. In accord with the new WHO Blue Book series, the actual classification is accompanied by extensive descriptions and illustrations of clinicopathological characteristics of each tumor type, including molecular genetic features, predictive factors, and separate chapters on inherited tumor syndromes. The 2000 WHO classification of nervous system tumors aims at being used and implemented by the neuro-oncology and biomedical research communities worldwide.

UR - http://www.scopus.com/inward/record.url?scp=0036192918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036192918&partnerID=8YFLogxK

M3 - Article

C2 - 11895036

AN - SCOPUS:0036192918

VL - 61

SP - 215

EP - 225

JO - American Journal of Psychotherapy

JF - American Journal of Psychotherapy

SN - 0002-9564

IS - 3

ER -