The VMAT2 gene in mice and humans: Amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins

G. R. Uhl, S. Li, N. Takahashi, K. Itokawa, Z. Lin, M. Hazama, I. Sora

Research output: Contribution to journalArticlepeer-review

Abstract

Monoamine compartmentalization in monoaminergic neurons uses serial action of the plasma membrane and vesicular monoamine (VAMT2) transporters. We can now define the sequences of the genes encoding these transporters in mice and humans, examine influences of deletions of this gene and alteration in its expression levels in transgenic mice, and identify sequence polymorphisms in the human VMAT2 gene. Examination of VMAT2 variants can provide potential insights into roles for allelic variants at these loci in variant drug responses and in diseases linked to monoaminergic systems, including substance abuse and Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)2459-2465
Number of pages7
JournalFASEB Journal
Volume14
Issue number15
StatePublished - 2000

Keywords

  • Dopamine
  • Histamine
  • MPTP
  • Norepinephrine
  • Parkinsonism
  • Serotonin
  • Synaptic vesicle
  • VMAT2

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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