The vitamin A and mortality paradigm: Past, present, and future

Research output: Contribution to journalArticle

Abstract

Vitamin A deficiency contributes to the morbidity and mortality from some infectious diseases. Empirical observations and trials from the early twentieth century led to the paradigm that improvement of vitamin A status could reduce morbidity and mortality among women and children. Many seminal observations of vitamin A deficiency and infection were made in Scandinavia. International organizations in the 1930s and 1940s emphasized adequate vitamin A status to prevent morbidity and mortality. With improvement of nutrition and hygiene in Europe and the United States, vitamin A deficiency largely disappeared, and attention later turned towards developing countries. Over one hundred clinical trials have addressed the impact of vitamin A on infectious disease morbidity and mortality and show that adequate vitamin A status is important in measles and diarrheal disease but not in non-measles pneumonia. Current studies extend investigations of the role of vitamin A to malaria, tuberculosis, and human immunodeficiency virus infection.

Original languageEnglish (US)
Pages (from-to)46-50
Number of pages5
JournalScandinavian Journal of Nutrition/Naringsforskning
Volume45
Issue number2
Publication statusPublished - 2001
Externally publishedYes

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Keywords

  • Immunity
  • Infection
  • Morbidity
  • Mortality
  • Vitamin A

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

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