Abstract
The Veterans Aging Cohort Study (VACS) Index has been associated with HIV-associated neurocognitive disorder (HAND) in some populations but has not been studied in sub-Saharan Africa. We investigated whether the VACS Index is associated with HAND in a rural population in Rakai, Uganda. HIV-infected (HIV+) adults on antiretroviral therapy underwent a neurocognitive battery for determination of HAND stage using Frascati criteria. VACS component scores were recorded for all participants. Out of 156 study participants, HAND stages were 49% normal cognition, 15% asymptomatic neurocognitive impairment, 31% minor neurocognitive disorder, and 7% HIV-associated dementia. There was no significant association between VACS Index and any HAND stage. In this first study of the VACS Index in sub-Saharan Africa, we found no association between VACS Index score and HAND.
| Original language | English (US) |
|---|---|
| Journal | Journal of neurovirology |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- Global health
- HIV
- HIV-associated neurocognitive disorder
- Uganda
- Veterans aging cohort study index
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Virology
Cite this
The Veterans Aging Cohort Study Index is not associated with HIV-associated neurocognitive disorders in Uganda. / Awori, Violet; Nakigozi, Gertrude; Kisakye, Alice; Batte, James; Anok, Aggrey; Mayanja, Richard; Nakasujja, Noeline; Robertson, Kevin R.; Gray, Ronald H.; Wawer, Maria J.; Sacktor, Ned; Saylor, Deanna.
In: Journal of neurovirology, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Veterans Aging Cohort Study Index is not associated with HIV-associated neurocognitive disorders in Uganda
AU - Awori, Violet
AU - Nakigozi, Gertrude
AU - Kisakye, Alice
AU - Batte, James
AU - Anok, Aggrey
AU - Mayanja, Richard
AU - Nakasujja, Noeline
AU - Robertson, Kevin R.
AU - Gray, Ronald H.
AU - Wawer, Maria J.
AU - Sacktor, Ned
AU - Saylor, Deanna
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The Veterans Aging Cohort Study (VACS) Index has been associated with HIV-associated neurocognitive disorder (HAND) in some populations but has not been studied in sub-Saharan Africa. We investigated whether the VACS Index is associated with HAND in a rural population in Rakai, Uganda. HIV-infected (HIV+) adults on antiretroviral therapy underwent a neurocognitive battery for determination of HAND stage using Frascati criteria. VACS component scores were recorded for all participants. Out of 156 study participants, HAND stages were 49% normal cognition, 15% asymptomatic neurocognitive impairment, 31% minor neurocognitive disorder, and 7% HIV-associated dementia. There was no significant association between VACS Index and any HAND stage. In this first study of the VACS Index in sub-Saharan Africa, we found no association between VACS Index score and HAND.
AB - The Veterans Aging Cohort Study (VACS) Index has been associated with HIV-associated neurocognitive disorder (HAND) in some populations but has not been studied in sub-Saharan Africa. We investigated whether the VACS Index is associated with HAND in a rural population in Rakai, Uganda. HIV-infected (HIV+) adults on antiretroviral therapy underwent a neurocognitive battery for determination of HAND stage using Frascati criteria. VACS component scores were recorded for all participants. Out of 156 study participants, HAND stages were 49% normal cognition, 15% asymptomatic neurocognitive impairment, 31% minor neurocognitive disorder, and 7% HIV-associated dementia. There was no significant association between VACS Index and any HAND stage. In this first study of the VACS Index in sub-Saharan Africa, we found no association between VACS Index score and HAND.
KW - Global health
KW - HIV
KW - HIV-associated neurocognitive disorder
KW - Uganda
KW - Veterans aging cohort study index
UR - http://www.scopus.com/inward/record.url?scp=85075200643&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075200643&partnerID=8YFLogxK
U2 - 10.1007/s13365-019-00806-2
DO - 10.1007/s13365-019-00806-2
M3 - Article
C2 - 31721082
AN - SCOPUS:85075200643
JO - Journal of NeuroVirology
JF - Journal of NeuroVirology
SN - 1355-0284
ER -