The Veterans Aging Cohort Study Index is not associated with HIV-associated neurocognitive disorders in Uganda

Violet Awori, Gertrude Nakigozi, Alice Kisakye, James Batte, Aggrey Anok, Richard Mayanja, Noeline Nakasujja, Kevin R. Robertson, Ronald H. Gray, Maria J. Wawer, Ned Sacktor, Deanna Saylor

Research output: Contribution to journalArticle

Abstract

The Veterans Aging Cohort Study (VACS) Index has been associated with HIV-associated neurocognitive disorder (HAND) in some populations but has not been studied in sub-Saharan Africa. We investigated whether the VACS Index is associated with HAND in a rural population in Rakai, Uganda. HIV-infected (HIV+) adults on antiretroviral therapy underwent a neurocognitive battery for determination of HAND stage using Frascati criteria. VACS component scores were recorded for all participants. Out of 156 study participants, HAND stages were 49% normal cognition, 15% asymptomatic neurocognitive impairment, 31% minor neurocognitive disorder, and 7% HIV-associated dementia. There was no significant association between VACS Index and any HAND stage. In this first study of the VACS Index in sub-Saharan Africa, we found no association between VACS Index score and HAND.

Original languageEnglish (US)
Pages (from-to)252-256
Number of pages5
JournalJournal of neurovirology
Volume26
Issue number2
DOIs
StatePublished - Apr 1 2020

Keywords

  • Global health
  • HIV
  • HIV-associated neurocognitive disorder
  • Uganda
  • Veterans aging cohort study index

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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