@article{4f401d6ac3d0469aa2e51bbfa091a5ef,
title = "The Veterans Aging Cohort Study Index is not associated with HIV-associated neurocognitive disorders in Uganda",
abstract = "The Veterans Aging Cohort Study (VACS) Index has been associated with HIV-associated neurocognitive disorder (HAND) in some populations but has not been studied in sub-Saharan Africa. We investigated whether the VACS Index is associated with HAND in a rural population in Rakai, Uganda. HIV-infected (HIV+) adults on antiretroviral therapy underwent a neurocognitive battery for determination of HAND stage using Frascati criteria. VACS component scores were recorded for all participants. Out of 156 study participants, HAND stages were 49% normal cognition, 15% asymptomatic neurocognitive impairment, 31% minor neurocognitive disorder, and 7% HIV-associated dementia. There was no significant association between VACS Index and any HAND stage. In this first study of the VACS Index in sub-Saharan Africa, we found no association between VACS Index score and HAND.",
keywords = "Global health, HIV, HIV-associated neurocognitive disorder, Uganda, Veterans aging cohort study index",
author = "Violet Awori and Gertrude Nakigozi and Alice Kisakye and James Batte and Aggrey Anok and Richard Mayanja and Noeline Nakasujja and Robertson, {Kevin R.} and Gray, {Ronald H.} and Wawer, {Maria J.} and Ned Sacktor and Deanna Saylor",
note = "Funding Information: Written informed consent was obtained from all study participants. This study was approved by the Western Institutional Review Board, the Uganda Virus Research Institute Research and Ethics Committee, and the Uganda National Council for Science and Technology. Funding Information: This study was supported by the National Institutes of Health (MH099733, MH075673, MH080661-08, L30NS088658, NS065729-05S2, P30AI094189-01A1) and the Johns Hopkins Center for Global Health. Funding Information: Written informed consent was obtained from all study participants. This study was approved by the Western Institutional Review Board, the Uganda Virus Research Institute Research and Ethics Committee, and the Uganda National Council for Science and Technology. Publisher Copyright: {\textcopyright} 2019, Journal of NeuroVirology, Inc.",
year = "2020",
month = apr,
day = "1",
doi = "10.1007/s13365-019-00806-2",
language = "English (US)",
volume = "26",
pages = "252--256",
journal = "Journal of NeuroVirology",
issn = "1355-0284",
publisher = "Springer New York",
number = "2",
}