The vasopressin gene is expressed prior to regulation in the supraoptic nuclei of fetal rats

Steven M. Reppert; George R. Uhl

doi:10.1016/0006-8993(88)90246-6

The vasopressin gene is expressed prior to regulation in the supraoptic nuclei of fetal rats

Steven M. Reppert, George R. Uhl

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The development of the regulation of vasopressin (prepropressophysin) mRNA in the supraoptic nuclei (SON) of rats was studied using quantitative in situ hybridization. On day 21 of gestation, vasopressin mRNA levels in the SON were increased by osmotic stimulation, with significant positive correlation between vasopressin mRNA levels and plasma osmolality. On day 19 of gestation, vasopressin mRNA levels in the SON were not significantly increased by osmotic stimulation, and no correlation between vasopressin mRNA levels and plasma osmolality was noted. The results suggest that the mechanisms for osmotic regulation of vasopressin mRNA levels develop between days 19 and 21 of gestation, a time course consistent with the initiation of afferent innervation of the SON.

Original language	English (US)
Pages (from-to)	392-396
Number of pages	5
Journal	Brain Research
Volume	456
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(88)90246-6
State	Published - Jul 26 1988
Externally published	Yes

Keywords

Fetus
Gene regulation
Supraoptic nucleus
Vasopressin

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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10.1016/0006-8993(88)90246-6

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title = "The vasopressin gene is expressed prior to regulation in the supraoptic nuclei of fetal rats",

abstract = "The development of the regulation of vasopressin (prepropressophysin) mRNA in the supraoptic nuclei (SON) of rats was studied using quantitative in situ hybridization. On day 21 of gestation, vasopressin mRNA levels in the SON were increased by osmotic stimulation, with significant positive correlation between vasopressin mRNA levels and plasma osmolality. On day 19 of gestation, vasopressin mRNA levels in the SON were not significantly increased by osmotic stimulation, and no correlation between vasopressin mRNA levels and plasma osmolality was noted. The results suggest that the mechanisms for osmotic regulation of vasopressin mRNA levels develop between days 19 and 21 of gestation, a time course consistent with the initiation of afferent innervation of the SON.",

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T1 - The vasopressin gene is expressed prior to regulation in the supraoptic nuclei of fetal rats

AU - Reppert, Steven M.

AU - Uhl, George R.

PY - 1988/7/26

Y1 - 1988/7/26

N2 - The development of the regulation of vasopressin (prepropressophysin) mRNA in the supraoptic nuclei (SON) of rats was studied using quantitative in situ hybridization. On day 21 of gestation, vasopressin mRNA levels in the SON were increased by osmotic stimulation, with significant positive correlation between vasopressin mRNA levels and plasma osmolality. On day 19 of gestation, vasopressin mRNA levels in the SON were not significantly increased by osmotic stimulation, and no correlation between vasopressin mRNA levels and plasma osmolality was noted. The results suggest that the mechanisms for osmotic regulation of vasopressin mRNA levels develop between days 19 and 21 of gestation, a time course consistent with the initiation of afferent innervation of the SON.

AB - The development of the regulation of vasopressin (prepropressophysin) mRNA in the supraoptic nuclei (SON) of rats was studied using quantitative in situ hybridization. On day 21 of gestation, vasopressin mRNA levels in the SON were increased by osmotic stimulation, with significant positive correlation between vasopressin mRNA levels and plasma osmolality. On day 19 of gestation, vasopressin mRNA levels in the SON were not significantly increased by osmotic stimulation, and no correlation between vasopressin mRNA levels and plasma osmolality was noted. The results suggest that the mechanisms for osmotic regulation of vasopressin mRNA levels develop between days 19 and 21 of gestation, a time course consistent with the initiation of afferent innervation of the SON.

KW - Fetus

KW - Gene regulation

KW - Supraoptic nucleus

KW - Vasopressin

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The vasopressin gene is expressed prior to regulation in the supraoptic nuclei of fetal rats

Abstract

Keywords

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