The value of visfatin in the prediction of metabolic syndrome: A multi-factorial analysis

Alireza Esteghamati, Afsaneh Morteza, Ali Zandieh, Samira Jafari, Mehdi Rezaee, Manouchehr Nakhjavani, Arsia Jamali, Abdoul Reza Esteghamati, Omid Khalilzadeh

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the adipokine concentration in patients with metabolic syndrome, stressing the role of visfatin. A cross-sectional single center study on 70 patients with metabolic syndrome plus 76 controls was performed. Patients with metabolic syndrome had higher visfatin levels compared to controls, following adjustments for age, sex, waist/hip circumference, systolic, and diastolic blood pressure, fasting plasma glucose (FPG), HbA1c, body mass index, and homeostasis model assessment of insulin resistance (HOMA-IR) [(5.39±0.29 vs. 3.88±0.32); F(1, 129)=10.8, P<0.01]. A logistic regression analysis revealed that circulating visfatin levels and HbA1c were the top variables for predicating metabolic syndrome. In patients with metabolic syndrome, visfatin did not correlate with any of the measured variables, with the single exception of adiponectin; in patients without metabolic syndrome, circulating visfatin levels were significantly associated with FPG, HbA1c, insulin, HOMA-IR, HDL, and triglyceride. These findings may contribute to our current knowledge about visfatin in metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)541-546
Number of pages6
JournalJournal of cardiovascular translational research
Volume5
Issue number4
DOIs
StatePublished - Aug 2012
Externally publishedYes

Keywords

  • Insulin
  • Metabolic syndrome
  • Visfatin

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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