The value of transgenic models for the study of neurodegenerative diseases

Donald L. Price, Philip Chun Wong, Alicja L. Markowska, Michael K. Lee, Gopal Thinakaren, Donald W. Cleveland, Sangram S. Sisodia, David R. Borchelt

Research output: Contribution to journalArticle

Abstract

Transgenic animal models are useful in studying the features of APP- and PS1-linked FAD and SOD1-linked FALS. These models help to investigate the nature of the cellular/biochemical/molecular alterations in neural tissue; the character and evolution of neuronal and/or glial abnormalities; the ways mutant proteins cause damage to neurons; and the biochemical pathways associated with cell death. New technologies will help to define changes in a variety of genes/gene products and the events and conformational changes in mutant proteins that are implicated in pathogenic cascades. It is hoped such study will result in novel treatments for testing in transgenic models that can then be translated into new treatments for human neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)179-191
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume920
StatePublished - 2000

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Neurodegenerative diseases
Mutant Proteins
Neurodegenerative Diseases
Genetically Modified Animals
Flavin-Adenine Dinucleotide
Genes
Neuroglia
Cell Death
Animal Models
Cell death
Technology
Neurons
Animals
Tissue
Testing
Protein
Gene
Neuron
Animal Model
Pathway

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Price, D. L., Wong, P. C., Markowska, A. L., Lee, M. K., Thinakaren, G., Cleveland, D. W., ... Borchelt, D. R. (2000). The value of transgenic models for the study of neurodegenerative diseases. Annals of the New York Academy of Sciences, 920, 179-191.

The value of transgenic models for the study of neurodegenerative diseases. / Price, Donald L.; Wong, Philip Chun; Markowska, Alicja L.; Lee, Michael K.; Thinakaren, Gopal; Cleveland, Donald W.; Sisodia, Sangram S.; Borchelt, David R.

In: Annals of the New York Academy of Sciences, Vol. 920, 2000, p. 179-191.

Research output: Contribution to journalArticle

Price, DL, Wong, PC, Markowska, AL, Lee, MK, Thinakaren, G, Cleveland, DW, Sisodia, SS & Borchelt, DR 2000, 'The value of transgenic models for the study of neurodegenerative diseases', Annals of the New York Academy of Sciences, vol. 920, pp. 179-191.
Price DL, Wong PC, Markowska AL, Lee MK, Thinakaren G, Cleveland DW et al. The value of transgenic models for the study of neurodegenerative diseases. Annals of the New York Academy of Sciences. 2000;920:179-191.
Price, Donald L. ; Wong, Philip Chun ; Markowska, Alicja L. ; Lee, Michael K. ; Thinakaren, Gopal ; Cleveland, Donald W. ; Sisodia, Sangram S. ; Borchelt, David R. / The value of transgenic models for the study of neurodegenerative diseases. In: Annals of the New York Academy of Sciences. 2000 ; Vol. 920. pp. 179-191.
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