The value of transgenic models for the study of neurodegenerative diseases

Donald L. Price; Philip C. Wong; Alicja L. Markowska; Michael K. Lee; Gopal Thinakaren; Donald W. Cleveland; Sangram S. Sisodia; David R. Borchelt

doi:10.1111/j.1749-6632.2000.tb06920.x

The value of transgenic models for the study of neurodegenerative diseases

Donald L. Price, Philip C. Wong, Alicja L. Markowska, Michael K. Lee, Gopal Thinakaren, Donald W. Cleveland, Sangram S. Sisodia, David R. Borchelt

School of Medicine

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Transgenic animal models are useful in studying the features of APP- and PS1-linked FAD and SOD1-linked FALS. These models help to investigate the nature of the cellular/biochemical/molecular alterations in neural tissue; the character and evolution of neuronal and/or glial abnormalities; the ways mutant proteins cause damage to neurons; and the biochemical pathways associated with cell death. New technologies will help to define changes in a variety of genes/gene products and the events and conformational changes in mutant proteins that are implicated in pathogenic cascades. It is hoped such study will result in novel treatments for testing in transgenic models that can then be translated into new treatments for human neurodegenerative diseases.

Original language	English (US)
Pages (from-to)	179-191
Number of pages	13
Journal	Annals of the New York Academy of Sciences
Volume	920
DOIs	https://doi.org/10.1111/j.1749-6632.2000.tb06920.x
State	Published - 2000

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/j.1749-6632.2000.tb06920.x

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abstract = "Transgenic animal models are useful in studying the features of APP- and PS1-linked FAD and SOD1-linked FALS. These models help to investigate the nature of the cellular/biochemical/molecular alterations in neural tissue; the character and evolution of neuronal and/or glial abnormalities; the ways mutant proteins cause damage to neurons; and the biochemical pathways associated with cell death. New technologies will help to define changes in a variety of genes/gene products and the events and conformational changes in mutant proteins that are implicated in pathogenic cascades. It is hoped such study will result in novel treatments for testing in transgenic models that can then be translated into new treatments for human neurodegenerative diseases.",

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AU - Wong, Philip C.

AU - Markowska, Alicja L.

AU - Lee, Michael K.

AU - Thinakaren, Gopal

AU - Cleveland, Donald W.

AU - Sisodia, Sangram S.

AU - Borchelt, David R.

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AB - Transgenic animal models are useful in studying the features of APP- and PS1-linked FAD and SOD1-linked FALS. These models help to investigate the nature of the cellular/biochemical/molecular alterations in neural tissue; the character and evolution of neuronal and/or glial abnormalities; the ways mutant proteins cause damage to neurons; and the biochemical pathways associated with cell death. New technologies will help to define changes in a variety of genes/gene products and the events and conformational changes in mutant proteins that are implicated in pathogenic cascades. It is hoped such study will result in novel treatments for testing in transgenic models that can then be translated into new treatments for human neurodegenerative diseases.

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The value of transgenic models for the study of neurodegenerative diseases

Abstract

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