The value of in vitro fertilization for the treatment of unexplained infertility

D. Navot, S. J. Muasher, S. Oehninger, H. C. Liu, L. L. Veeck, D. Kreiner, Z. Rosenwaks

Research output: Contribution to journalArticle

Abstract

In 54 patients referred with the diagnosis of unexplained infertility (UI), the diagnosis was confirmed in 26 (strict UI) (48%). Minimal abnormalities (MA) were found in 19 (35%); 9 (17%) had gross abnormalities and were excluded from analysis. Fifty patients with tubal infertility were randomly assigned to form a control group. Mean age and type of stimulation did not differ in the two groups. Peak follicular estradiol (E2) and terminal follicular E2 patterns were comparable. There was no difference in the mean number of oocytes retrieved per cycle. However, the control group had significantly more preovulatory oocytes: 3.6 ± 2.0 standard deviations versus 2.8 ± 2.1 in the overall UI group (strict UI + MA groups) and 2.7 ± 2.2 in the strict UI group. Significantly more fertilized oocytes per cycle were obtained in the control group (P <0.05). The per-cycle and per-embryo transfer (ET) pregnancy rates were 32.4 and 37.3% in the overall UI group and 24 and 24.5% in the control group. The miscarriage rate was 12% in the strict UI group, 22% in the overall UI group, and 25% in the control group. It is concluded that patients with UI constitute a favorable group for in vitro fertilization and ET.

Original languageEnglish (US)
Pages (from-to)854-857
Number of pages4
JournalFertility and Sterility
Volume49
Issue number5
StatePublished - 1988
Externally publishedYes

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Fertilization in Vitro
Infertility
Control Groups
Oocytes
Therapeutics
Embryo Transfer
Spontaneous Abortion
Pregnancy Rate
Estradiol

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Navot, D., Muasher, S. J., Oehninger, S., Liu, H. C., Veeck, L. L., Kreiner, D., & Rosenwaks, Z. (1988). The value of in vitro fertilization for the treatment of unexplained infertility. Fertility and Sterility, 49(5), 854-857.

The value of in vitro fertilization for the treatment of unexplained infertility. / Navot, D.; Muasher, S. J.; Oehninger, S.; Liu, H. C.; Veeck, L. L.; Kreiner, D.; Rosenwaks, Z.

In: Fertility and Sterility, Vol. 49, No. 5, 1988, p. 854-857.

Research output: Contribution to journalArticle

Navot, D, Muasher, SJ, Oehninger, S, Liu, HC, Veeck, LL, Kreiner, D & Rosenwaks, Z 1988, 'The value of in vitro fertilization for the treatment of unexplained infertility', Fertility and Sterility, vol. 49, no. 5, pp. 854-857.
Navot D, Muasher SJ, Oehninger S, Liu HC, Veeck LL, Kreiner D et al. The value of in vitro fertilization for the treatment of unexplained infertility. Fertility and Sterility. 1988;49(5):854-857.
Navot, D. ; Muasher, S. J. ; Oehninger, S. ; Liu, H. C. ; Veeck, L. L. ; Kreiner, D. ; Rosenwaks, Z. / The value of in vitro fertilization for the treatment of unexplained infertility. In: Fertility and Sterility. 1988 ; Vol. 49, No. 5. pp. 854-857.
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