The utility of skin biopsy for prediction of progression in suspected small fiber neuropathy

C. H. Gibbons, J. W. Griffin, M. Polydefkis, I. Bonyhay, A. Brown, P. E. Hauer, J. C. McArthur

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-eight patients with sensory complaints of unknown etiology had repeated skin biopsies. Patients with large nerve fiber swellings on initial biopsy showed a decline in epidermal nerve fiber density on repeated biopsies (p < 0.05 within group; p < 0.05 vs those without swellings). Patients without nerve fiber swellings did not have changes in nerve fiber density between biopsies. Patients with large nerve fiber swellings were most likely to present clinically with paresthesias (p < 0.05).

Original languageEnglish (US)
Pages (from-to)256-258
Number of pages3
JournalNeurology
Volume66
Issue number2
DOIs
StatePublished - Jan 2006

ASJC Scopus subject areas

  • Clinical Neurology

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