The utility of skin biopsy for prediction of progression in suspected small fiber neuropathy

C. H. Gibbons; J. W. Griffin; M. Polydefkis; I. Bonyhay; A. Brown; P. E. Hauer; J. C. McArthur

doi:10.1212/01.wnl.0000194314.86486.a2

The utility of skin biopsy for prediction of progression in suspected small fiber neuropathy

C. H. Gibbons, J. W. Griffin, M. Polydefkis, I. Bonyhay, A. Brown, P. E. Hauer, J. C. McArthur

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Twenty-eight patients with sensory complaints of unknown etiology had repeated skin biopsies. Patients with large nerve fiber swellings on initial biopsy showed a decline in epidermal nerve fiber density on repeated biopsies (p < 0.05 within group; p < 0.05 vs those without swellings). Patients without nerve fiber swellings did not have changes in nerve fiber density between biopsies. Patients with large nerve fiber swellings were most likely to present clinically with paresthesias (p < 0.05).

Original language	English (US)
Pages (from-to)	256-258
Number of pages	3
Journal	Neurology
Volume	66
Issue number	2
DOIs	https://doi.org/10.1212/01.wnl.0000194314.86486.a2
State	Published - Jan 2006

ASJC Scopus subject areas

Clinical Neurology

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abstract = "Twenty-eight patients with sensory complaints of unknown etiology had repeated skin biopsies. Patients with large nerve fiber swellings on initial biopsy showed a decline in epidermal nerve fiber density on repeated biopsies (p < 0.05 within group; p < 0.05 vs those without swellings). Patients without nerve fiber swellings did not have changes in nerve fiber density between biopsies. Patients with large nerve fiber swellings were most likely to present clinically with paresthesias (p < 0.05).",

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AU - Griffin, J. W.

AU - Polydefkis, M.

AU - Bonyhay, I.

AU - Brown, A.

AU - Hauer, P. E.

AU - McArthur, J. C.

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AB - Twenty-eight patients with sensory complaints of unknown etiology had repeated skin biopsies. Patients with large nerve fiber swellings on initial biopsy showed a decline in epidermal nerve fiber density on repeated biopsies (p < 0.05 within group; p < 0.05 vs those without swellings). Patients without nerve fiber swellings did not have changes in nerve fiber density between biopsies. Patients with large nerve fiber swellings were most likely to present clinically with paresthesias (p < 0.05).

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The utility of skin biopsy for prediction of progression in suspected small fiber neuropathy

Abstract

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