The utility of onyx for preoperative embolization of cranial and spinal tumors

Pankaj Gore, Nicholas Theodore, Leonardo Brasiliense, Louis J. Kim, Mark Garrett, Peter Nakaji, L. Fernando Gonzalez, Cameron McDougall, Felipe C. Albuquerque

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To assess the utility, technical factors, and complications associated with the use of Onyx (Micro Therapeutics, Inc., Irvine, CA) for preoperative embolization of cranial and spinal tumors. METHODS: We reviewed a prospectively accumulated database for patients in whom Onyx was used for preoperative embolization of cranial and spinal tumors over a 19-month period. The patients' demographic characteristics, tumor type and location, embolic agents used, arteries catheterized, and associated complications were assessed. Specific attention was focused on technical factors associated with the use of Onyx that differed from the use of other commonly used embolic materials. RESULTS: Ten patients (four female and six male; age range, 11-60 yr) underwent preoperative embolization with Onyx before cranial or spinal tumor resection. Tumors included three juvenile nasal angiofibromas, two meningiomas, two hemangioblastomas, two metastases (renal cell and thyroid), and one giant cell tumor. Onyx embolization was performed in 43 vessels over 11 treatment sessions. There were no complications related to the embolization procedures. Deep penetration of the embolic agent into the tumor was documented through preoperative imaging or surgical pathological specimens. CONCLUSION: Preoperative embolization of cranial and spinal tumors can be performed safely. Specific technical advantages of Onyx included deep penetration of lesions producing extensive tumor infarction, the ability to embolize extensive portions of the tumors through fewer arterial catheterizations, and the safety of catheter withdrawal despite often substantial reflux along the embolic catheter.

Original languageEnglish (US)
Pages (from-to)1204-1211
Number of pages8
JournalNeurosurgery
Volume62
Issue number6
DOIs
StatePublished - Jun 2008
Externally publishedYes

Fingerprint

Neoplasms
Catheters
Angiofibroma
Hemangioblastoma
Giant Cell Tumors
Meningioma
Nose
Catheterization
Infarction
Thyroid Gland
Arteries
Demography
Databases
Neoplasm Metastasis
Kidney
Safety
Therapeutics

Keywords

  • Embolization
  • Onyx
  • Tumors

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Gore, P., Theodore, N., Brasiliense, L., Kim, L. J., Garrett, M., Nakaji, P., ... Albuquerque, F. C. (2008). The utility of onyx for preoperative embolization of cranial and spinal tumors. Neurosurgery, 62(6), 1204-1211. https://doi.org/10.1227/01.neu.0000333292.74986.ac

The utility of onyx for preoperative embolization of cranial and spinal tumors. / Gore, Pankaj; Theodore, Nicholas; Brasiliense, Leonardo; Kim, Louis J.; Garrett, Mark; Nakaji, Peter; Gonzalez, L. Fernando; McDougall, Cameron; Albuquerque, Felipe C.

In: Neurosurgery, Vol. 62, No. 6, 06.2008, p. 1204-1211.

Research output: Contribution to journalArticle

Gore, P, Theodore, N, Brasiliense, L, Kim, LJ, Garrett, M, Nakaji, P, Gonzalez, LF, McDougall, C & Albuquerque, FC 2008, 'The utility of onyx for preoperative embolization of cranial and spinal tumors', Neurosurgery, vol. 62, no. 6, pp. 1204-1211. https://doi.org/10.1227/01.neu.0000333292.74986.ac
Gore, Pankaj ; Theodore, Nicholas ; Brasiliense, Leonardo ; Kim, Louis J. ; Garrett, Mark ; Nakaji, Peter ; Gonzalez, L. Fernando ; McDougall, Cameron ; Albuquerque, Felipe C. / The utility of onyx for preoperative embolization of cranial and spinal tumors. In: Neurosurgery. 2008 ; Vol. 62, No. 6. pp. 1204-1211.
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