The utility of menstrual cycle length as an indicator of cumulative hormonal exposure

Sunni L. Mumford, Anne Z. Steiner, Anna Z. Pollack, Neil J. Perkins, Amanda C. Filiberto, Paul S. Albert, Donald R. Mattison, Jean Wactawski-Wende, Enrique F. Schisterman

Research output: Contribution to journalArticle

Abstract

Context: Associations between menstrual cycle length and chronic diseases are hypothesized to be due to differences in underlying hormonal patterns. Objective: Theaimof the studywasto evaluate the associationbetweenmenstrual cycle lengthand the hormonal profile and anovulation. Design and Setting: We conducted a prospective cohort study at the University at Buffalo from 2005 to 2007. Participants: We recruited 259 healthy, regularly menstruating women aged 18-44 yr. Main Outcome Measures: Cycle length was observed for up to two cycles. Serum estradiol, progesterone, LH, and FSH were measured up to eight times per cycle for up to two cycles. Results: Women with short cycles (35 d), estradiol and LH peaks occurred on average about 3 d later, and FSH peaks about 1 d later compared to women with normal-length cycles. Both short and long cycles, compared with normal-length cycles, had an increased probability of anovulation. In general, per-cycle exposure to hormones was less in short cycles based on the area under the curve, although over time the cumulative exposure to estradiol would be greater for women with short cycles. Conclusions: Short ovulatory cycles were associated with higher follicular phase estradiol, an earlier rise in FSH, and an increased risk of anovulation. These results suggest that menstrual cycle length may be a relevant indicator of estradiol exposure and risk of anovulation among regularly cycling women.

Original languageEnglish (US)
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number10
DOIs
StatePublished - Oct 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

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    Mumford, S. L., Steiner, A. Z., Pollack, A. Z., Perkins, N. J., Filiberto, A. C., Albert, P. S., Mattison, D. R., Wactawski-Wende, J., & Schisterman, E. F. (2012). The utility of menstrual cycle length as an indicator of cumulative hormonal exposure. Journal of Clinical Endocrinology and Metabolism, 97(10). https://doi.org/10.1210/jc.2012-1350