TY - JOUR
T1 - The use of stereotactic radiosurgery for the treatment of spinal axis tumors
T2 - A review
AU - Bydon, Mohamad
AU - De La Garza-Ramos, Rafael
AU - Bettagowda, Chetan
AU - Gokaslan, Ziya L.
AU - Sciubba, Daniel M.
PY - 2014/10
Y1 - 2014/10
N2 - As the prevalence of cancer in the general population increases, a greater proportion of patients will present with symptomatic metastatic lesions to the spine. While surgery has been historically considered the treatment of choice for spinal cord/nerve root compression, mechanical instability and intractable pain, radiation therapy - particularly stereotactic radiosurgery (SRS) - has been increasingly used as either a primary or adjuvant treatment modality. In this manuscript, the authors perform a review on the principles behind SRS and its use in the treatment of spinal tumors, specifically primary and secondary malignant tumors. In the last decades, numerous retrospective studies have shown the feasibility of SRS as both primary treatment for malignant tumors, as well as adjuvant treatment following surgical resection. Although local control rates may reach 90%, future studies are warranted to determine optimal doses, fractionation of therapy and the long-term implications of irradiation to neural structures.
AB - As the prevalence of cancer in the general population increases, a greater proportion of patients will present with symptomatic metastatic lesions to the spine. While surgery has been historically considered the treatment of choice for spinal cord/nerve root compression, mechanical instability and intractable pain, radiation therapy - particularly stereotactic radiosurgery (SRS) - has been increasingly used as either a primary or adjuvant treatment modality. In this manuscript, the authors perform a review on the principles behind SRS and its use in the treatment of spinal tumors, specifically primary and secondary malignant tumors. In the last decades, numerous retrospective studies have shown the feasibility of SRS as both primary treatment for malignant tumors, as well as adjuvant treatment following surgical resection. Although local control rates may reach 90%, future studies are warranted to determine optimal doses, fractionation of therapy and the long-term implications of irradiation to neural structures.
KW - Spinal metastases
KW - Spinal surgery
KW - Spinal tumor
KW - Stereotactic radiosurgery
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U2 - 10.1016/j.clineuro.2014.08.003
DO - 10.1016/j.clineuro.2014.08.003
M3 - Review article
C2 - 25156410
AN - SCOPUS:84906703444
SN - 0303-8467
VL - 125
SP - 166
EP - 172
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
ER -