The Use of Protease Inhibitors in Pregnancy: Maternal and Fetal Considerations

Elaine Duryea, Fiona Nicholson, Sara Cooper, Scott Roberts, Vanessa Rogers, Donald McIntire, Jeanne Sheffield, Robert Stewart

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Abstract

Background. Previous studies examining protease inhibitor use in pregnancy and the rate of preterm and small-for-gestational-age infants have yielded conflicting results. Methods. This was a retrospective study of HIV-infected women who delivered singleton infants at our institution between 1984 and 2014. Women with protease inhibitor use were compared to women on regimens without a protease inhibitor as well as those who received no antepartum antiretroviral therapy. Infants were considered preterm if less than 37 completed weeks of gestation and small-for-gestational-age if less than 10th percentile. Results. During the study period 1,004 pregnancies met inclusion criteria. Of those, 597 received a protease inhibitor as part of their regimen, 230 ART without a protease inhibitor, and 177 no ART. There was no difference in the rate of preterm birth between groups who received ART with or without a protease inhibitor, 14% versus 13%. There was no difference in the rate of small-for-gestational-age infants between the three groups. Use of a protease inhibitor was associated with a greater fall in viral load during pregnancy, p<0.001. Conclusion. In this population with access to prenatal care and ART, treatment with protease inhibitors was associated with a greater fall in viral load, but not an increase in small or preterm infants.

Original languageEnglish (US)
Article number563727
JournalInfectious Diseases in Obstetrics and Gynecology
Volume2015
DOIs
StatePublished - Jan 1 2015

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ASJC Scopus subject areas

  • Dermatology
  • Obstetrics and Gynecology
  • Infectious Diseases

Cite this

Duryea, E., Nicholson, F., Cooper, S., Roberts, S., Rogers, V., McIntire, D., Sheffield, J., & Stewart, R. (2015). The Use of Protease Inhibitors in Pregnancy: Maternal and Fetal Considerations. Infectious Diseases in Obstetrics and Gynecology, 2015, [563727]. https://doi.org/10.1155/2015/563727