The use of prostate-specific antigen as a surrogate end point in the treatment of patients with hormone refractory prostate cancer

D. C. Smith, K. J. Pienta

Research output: Contribution to journalArticle

Abstract

Prostate-specific antigen increasingly is being used as a surrogate end point in trials of new agents in patients with hormone refractory prostate cancer. This article reviews data that support this marker as a surrogate end point and the contradictory data reported recently for trials of suramin. These contrasting views may originate in the different mechanisms of actions of the agents studied. These data suggest that a decline in prostate-specific antigen of at least 50% from baseline may be an important predictor of survivial for patients receiving cytotoxic therapy.

Original languageEnglish (US)
Pages (from-to)433-437
Number of pages5
JournalUrologic Clinics of North America
Volume24
Issue number2
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Urology

Cite this