The use of nuclear morphometry to predict prognosis in pediatric urologic malignancies: A review

Alan Wayne Partin, John Phillip Gearhart, M. P. Leonard, B. G. Leventhal, J. K. Yoo, D. Crooks, Jonathan Ira Epstein, J. B. Beckwith

Research output: Contribution to journalArticle

Abstract

Wilms tumor, the most common pediatric urologic malignancy, and genitourinary rhabdomyosarcoma, the most common soft tissue sarcoma of childhood, represent two of the most commonly diagnosed pediatric urologic malignancies. The introduction and use of multimodal therapy (surgery, radiation, and chemotherapy) by the National Wilms Tumor Study (NWTS) and the Intergroup Rhabdomyosarcoma Study (IRS) groups have greatly improved the survival among children with these malignancies. Present survival rates for Wilms tumor exceed 85% and for rhabdomyosarcoma survival rates are approaching 80% as well. For Wilms tumor, current treatment trends suggest less intense therapy for those children with favorable histology tumors who are considered at relatively low risk for tumor recurrence. Likewise, the significant morbidity associated with the present therapy regimens for rhabdomyosarcomas has prompted investigators to search for individualized management schemes for children with a high probability of responding. The need for accurate criteria to separate these high and low risk groups becomes imperative. In this review we present our work using nuclear morphometry, as a prognostic indicator, to retrospectively predict response to therapy for children with Wilms tumors and genitourinary rhabdomyosarcomas.

Original languageEnglish (US)
Pages (from-to)222-229
Number of pages8
JournalMedical and Pediatric Oncology
Volume21
Issue number3
StatePublished - 1993

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Wilms Tumor
Rhabdomyosarcoma
Pediatrics
Neoplasms
Survival Rate
Therapeutics
Sarcoma
Histology
Radiotherapy
Research Personnel
Morbidity
Recurrence
Drug Therapy

Keywords

  • genitourinary rhabdomyosarcoma
  • Wilms tumor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Cite this

Partin, A. W., Gearhart, J. P., Leonard, M. P., Leventhal, B. G., Yoo, J. K., Crooks, D., ... Beckwith, J. B. (1993). The use of nuclear morphometry to predict prognosis in pediatric urologic malignancies: A review. Medical and Pediatric Oncology, 21(3), 222-229.

The use of nuclear morphometry to predict prognosis in pediatric urologic malignancies : A review. / Partin, Alan Wayne; Gearhart, John Phillip; Leonard, M. P.; Leventhal, B. G.; Yoo, J. K.; Crooks, D.; Epstein, Jonathan Ira; Beckwith, J. B.

In: Medical and Pediatric Oncology, Vol. 21, No. 3, 1993, p. 222-229.

Research output: Contribution to journalArticle

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