The use of hybridoma antibodies to probe the antigenic determinants of thyroglobulin.

N. R. Rose, M. Accavitti, E. F. Pydyn, M. A. Leon, R. K. Brown

Research output: Contribution to journalArticlepeer-review

Abstract

Using monoclonal antibodies we have begun to define the epitopes of the murine thyroglobulin molecule that elicit autoimmune responses. Based on the principle of complementation, 18 monoclonal antibodies were classified into 8 groups, defined by their reactions with the same or neighboring determinants. Further distinctions between the monoclonals were drawn from comparisons of their cross-reactions with thyroglobulins of other species and their patterns in isoelectric focusing. One low molecular weight fragment of bovine thyroglobulin, which cross-reacts extensively with thyroglobulins of other species, has been isolated and partially characterized.

Original languageEnglish (US)
Pages (from-to)23-35
Number of pages13
JournalAdvances in experimental medicine and biology
Volume150
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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